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CDK1 and LZTS1
Number of citations of the paper that reports this interaction (PubMedID
11504921
)
30
Data Source:
HPRD
(in vivo)
CDK1
LZTS1
Description
cyclin dependent kinase 1
leucine zipper tumor suppressor 1
Image
No pdb structure
GO Annotations
Cellular Component
Cyclin-dependent Protein Kinase Holoenzyme Complex
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Matrix
Endoplasmic Reticulum Membrane
Centrosome
Cytosol
Spindle Microtubule
Membrane
Midbody
Extracellular Exosome
Mitotic Spindle
Cyclin B1-CDK1 Complex
Cytoplasm
Postsynaptic Density
Apical Plasma Membrane
Dendritic Spine
Dendritic Shaft
Cell Body
Postsynaptic Membrane
Molecular Function
Virus Receptor Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity
Cyclin Binding
Histone Kinase Activity
Cyclin-dependent Protein Kinase Activity
Protein Serine Kinase Activity
Protein Binding
Microtubule Binding
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Microtubule Cytoskeleton Organization
DNA Replication
DNA Repair
Protein Phosphorylation
Apoptotic Process
Mitotic G2 DNA Damage Checkpoint Signaling
Centrosome Cycle
Pronuclear Fusion
Cell Aging
Response To Xenobiotic Stimulus
Response To Toxic Substance
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Regulation Of Schwann Cell Differentiation
Response To Organic Cyclic Compound
Response To Amine
Response To Activity
Cell Migration
Histone Phosphorylation
Protein Deubiquitination
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Chromosome Condensation
Epithelial Cell Differentiation
Animal Organ Regeneration
Protein Localization To Kinetochore
Positive Regulation Of Protein Import Into Nucleus
Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Response To Ethanol
Positive Regulation Of DNA Replication
Regulation Of Embryonic Development
Response To Cadmium Ion
Response To Copper Ion
Viral Entry Into Host Cell
Rhythmic Process
Response To Axon Injury
Cell Division
Ventricular Cardiac Muscle Cell Development
Positive Regulation Of Cardiac Muscle Cell Proliferation
Protein-containing Complex Assembly
Cellular Response To Hydrogen Peroxide
ERK1 And ERK2 Cascade
Golgi Disassembly
Positive Regulation Of Protein Localization To Nucleus
Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport
Negative Regulation Of Macroautophagy
Mitotic Cell Cycle Phase Transition
Regulation Of Synaptic Plasticity
Regulation Of Dendrite Morphogenesis
Pathways
MAPK3 (ERK1) activation
E2F-enabled inhibition of pre-replication complex formation
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
Golgi Cisternae Pericentriolar Stack Reorganization
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes
APC/C:Cdc20 mediated degradation of Cyclin B
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Regulation of APC/C activators between G1/S and early anaphase
Phosphorylation of the APC/C
Phosphorylation of Emi1
Condensation of Prophase Chromosomes
MASTL Facilitates Mitotic Progression
Resolution of Sister Chromatid Cohesion
Condensation of Prometaphase Chromosomes
Regulation of PLK1 Activity at G2/M Transition
Activation of NIMA Kinases NEK9, NEK6, NEK7
Initiation of Nuclear Envelope (NE) Reformation
Nuclear Pore Complex (NPC) Disassembly
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Depolymerisation of the Nuclear Lamina
Anchoring of the basal body to the plasma membrane
MAPK6/MAPK4 signaling
Ovarian tumor domain proteases
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Regulation of TP53 Degradation
Mitotic Prophase
G1/S-Specific Transcription
Cyclin A/B1/B2 associated events during G2/M transition
Cyclin A/B1/B2 associated events during G2/M transition
G2/M DNA replication checkpoint
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
The role of GTSE1 in G2/M progression after G2 checkpoint
AURKA Activation by TPX2
Transcriptional regulation by RUNX2
Drugs
Indirubin-3'-monoxime
Olomoucine
Hymenialdisine
SU9516
Alvocidib
Alsterpaullone
Seliciclib
AT-7519
Fostamatinib
Diseases
GWAS
Cocaine dependence (
23958962
)
Voxel-wise structural brain imaging measurements in Alzheimer’s disease (
31095298
)
Adult body size (
32376654
)
Circulating myeloperoxidase levels (serum) (
23620142
)
Dental caries (
23064961
23259602
)
Influenza A (H1N1) infection (
26379185
)
Interleukin-6 levels (
33517400
)
Major depressive disorder (broad) (
20038947
)
Persistent hepatitis B virus infection (
27244555
)
Preeclampsia (
23551011
)
Rheumatoid arthritis (
30891314
)
Severe influenza A (H1N1) infection (
26379185
)
Interacting Genes
188 interacting genes:
ABL1
AMPH
APLP2
AR
ARID4A
BARD1
BCL2
BIRC5
BIRC6
BRCA1
BRCA2
BTRC
BUB1
CALD1
CCNA1
CCNA2
CCNB1
CCNB1IP1
CCNB2
CCNE1
CCP110
CD8A
CDC20
CDC25A
CDC25B
CDC25C
CDC6
CDCA2
CDCA5
CDK7
CDKN1A
CDKN1B
CDKN3
CDT1
CEP55
CEP63
CHAF1B
CIITA
CKS2
CNOT7
CREM
CSN2
CSNK2A1
CSNK2B
CTNNB1
CUX1
CXCR1
DAB2
DCTN6
DNM2
DTL
DUT
E2F1
ECT2
EEF1D
EEF2K
EGFR
EP300
EPN1
ERCC2
FANCA
FANCC
FANCG
FBXO5
FEN1
FOXM1
FYN
GADD45A
GADD45B
GADD45G
GATA2
GBF1
GFAP
GOLGA2
GORASP1
H1-0
H1-1
H1-3
H1-5
H2AC4
H2BC3
H4C1
HMGA1
HMGA2
HMGB1
HSPA2
HTRA2
IL16
IL3RA
IPO13
ITGB3
ITPR1
JAK3
KAT5
KHDRBS1
KIF11
KIF20B
KIF26B
KMT2E
KRT18
LATS1
LMNA
LMNB1
LYN
LZTS1
MAP4
MAPT
MBP
MCM4
MDM4
MEF2C
MKI67
MLKL
MNDA
MYC
MYT1
NCAPD2
NCAPG
NCAPH
NCL
NDE1
NES
NPM1
NSFL1C
NUP210
PAK6
PBK
PCNA
PIN1
PITPNM1
PKMYT1
PLEC
PML
POLA1
PPP2R1A
PPP2R1B
PPP2R2B
PRC1
PTCH1
PTMA
PTPN1
PTPN2
PTPN6
PTTG1
RAB4A
RAB5B
RACGAP1
RAP1GAP
RB1
RCC1
RELB
REPS2
RFX3
RGCC
RPA2
RPS6KB1
RRM2
RUNX1
RUNX2
SFN
SP1
SPAG5
SQSTM1
SRC
SSBP1
STK3
STMN1
STMN2
TFDP1
TGFBR2
TK1
TLE1
TNNC1
TOP2A
TP53
TP53BP1
TP73
TSC1
TSPYL2
UBA1
UBE2A
UBE3A
UHRF2
USP16
VIM
WEE1
XIAP
ZBTB16
103 interacting genes:
AGTR1
AMOT
AP1M1
ARID5B
BYSL
CARD9
CBR1
CCDC102B
CCDC120
CCDC13
CCDC187
CCDC57
CCHCR1
CDC23
CDC25C
CDC37
CDC7
CDK1
CEP83
CKS1B
COG2
COPB1
CWF19L2
DDX6
EEF1G
ELOA
ENKD1
EXOC8
FAM161A
FAM161B
FAM50B
FAM71F1
FAM81B
FAM90A1
GAS8
GOLGA1
GPKOW
HMGB2
IDO2
KANK2
KAT5
KAZN
KDM1A
KIF9
KIFC3
LENG1
LMNB2
LMO1
LMO2
LMO3
LMO4
LNX1
LSM2
MAPK9
MCRS1
METTL21A
MFAP1
MID2
NEK6
NTAQ1
PIBF1
PICK1
PLEKHA7
POLR1C
POLR3C
PPP1R18
PRKAB2
PRPF18
PRPF3
PSMA1
PSPC1
QARS1
RABIF
RHPN1
RSPH14
RUNX1T1
SCNM1
SGF29
SOGA1
SOX7
SPDYC
SUFU
SYT17
SYT6
SYTL4
TBC1D1
TBC1D7
TCEA2
TSGA10
TSGA10IP
TTC9C
TXLNA
TXLNB
TXNDC9
UBASH3A
ZGPAT
ZMYND19
ZNF250
ZNF3
ZNF35
ZNF417
ZNF572
ZNF587
Entrez ID
983
11178
HPRD ID
00302
05945
Ensembl ID
ENSG00000170312
ENSG00000061337
Uniprot IDs
A0A024QZJ8
B7Z3D6
I6L9I5
P06493
Q9Y250
PDB IDs
1LC9
4Y72
4YC3
4YC6
5HQ0
5LQF
6GU2
6GU3
6GU4
6GU6
6GU7
Enriched GO Terms of Interacting Partners
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