EBI3 and IL27RA

Number of citations of the paper that reports this interaction (PubMedID 12121660)
437

Data Source:
HPRD (in vivo, in vitro)

		EBI3	IL27RA
Description		Epstein-Barr virus induced 3	interleukin 27 receptor subunit alpha
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane External Side Of Plasma Membrane Receptor Complex	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Interleukin-12 Receptor Complex Receptor Complex Interleukin-23 Receptor Complex
	Molecular Function	Cytokine Receptor Activity Cytokine Activity Protein Binding Peptide Hormone Binding Cytokine Binding	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Interleukin-12 Receptor Binding Protein Binding Cytokine Binding Interleukin-23 Binding Interleukin-27 Receptor Activity
	Biological Process	Humoral Immune Response Cytokine-mediated Signaling Pathway Positive Regulation Of Interferon-gamma Production Leptin-mediated Signaling Pathway T-helper 1 Type Immune Response Positive Regulation Of Alpha-beta T Cell Proliferation	Positive Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Type 2 Immune Response Immune Response Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Activated T Cell Proliferation Regulation Of Isotype Switching To IgG Isotypes Defense Response To Gram-positive Bacterium Interleukin-27-mediated Signaling Pathway Negative Regulation Of T-helper 17 Type Immune Response Negative Regulation Of T Cell Extravasation
Pathways		Interleukin-35 Signalling Interleukin-27 signaling	Interleukin-35 Signalling Interleukin-27 signaling Interleukin-27 signaling
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Triglyceride levels ( 32154731)	Blood protein levels ( 30072576 29875488) Immune response to measles-mumps-rubella vaccine ( 24811271) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494)
Interacting Genes		6 interacting genes: CANX GOSR1 IL12A IL27RA MDFI SMAD3	13 interacting genes: BRICD5 CLDN2 DEFB121 DERL3 EBI3 GALNT15 GDF15 IL27 MAPK8 MFSD5 SLC41A2 STAT1 YIPF6
Entrez ID		10148	9466
HPRD ID		12051	09247
Ensembl ID		ENSG00000105246	ENSG00000104998
Uniprot IDs		Q14213	Q6UWB1
PDB IDs
Enriched GO Terms of Interacting Partners?
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