PLAA and KPNA4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		PLAA	KPNA4
Description		phospholipase A2 activating protein	karyopherin subunit alpha 4
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Synapse Extracellular Exosome	Nucleus Nucleoplasm Cytosol Nuclear Membrane
	Molecular Function	Protein Binding Phospholipase A2 Activator Activity Ubiquitin Binding	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity
	Biological Process	Phospholipid Metabolic Process Prostaglandin Metabolic Process Inflammatory Response Signal Transduction Nervous System Development Ubiquitin Recycling Macroautophagy Positive Regulation Of Phospholipase A2 Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Cellular Response To Lipopolysaccharide Negative Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Dendrite Extension Positive Regulation Of Neuron Migration	NLS-bearing Protein Import Into Nucleus
Pathways			ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways
Drugs
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Metabolite levels ( 23823483) Schizophrenia ( 20185149)	Alanine aminotransferase levels ( 33547301) Alcohol use disorder (total score) ( 30336701) Aspartate aminotransferase levels ( 33547301) Attention deficit hyperactivity disorder ( 32279069) Bipolar disorder ( 31043756) Malaria ( 31844061) Myeloproliferative neoplasms ( 33057200) Pit-and-Fissure caries ( 24556642) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Smooth-surface caries ( 24556642) Total cholesterol levels ( 30275531)
Interacting Genes		6 interacting genes: HDAC6 KPNA4 PLA2G1B UBC UBXN1 VCP	27 interacting genes: APP CDKN1B CSE1L CSNK2A1 CUL4B CYHR1 EXO1 FAM50B GTF2IRD1 HIF1A HNRNPC HSD3B7 KAT5 KPNB1 MAT2B MTA1 NCBP3 NFE2L2 NTRK3 NUP50 OGT PLAA RAC1 RCC1 RECQL TGM2 WT1
Entrez ID		9373	3840
HPRD ID		04850	04275
Ensembl ID		ENSG00000137055	ENSG00000186432
Uniprot IDs		Q9Y263	O00629
PDB IDs		2K89 2K8A 2K8B 2K8C 3EBB	4UAE 5TBK 5XZX 6BVV 6BVZ 6BW9 6BWA 6BWB 6WX8 7JJL
Enriched GO Terms of Interacting Partners?
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