PLAA and UBXN1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid, two hybrid, biochemical)

		PLAA	UBXN1
Description		phospholipase A2 activating protein	UBX domain protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Synapse Extracellular Exosome	Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Dendrite VCP-NPL4-UFD1 AAA ATPase Complex Neuronal Cell Body
	Molecular Function	Protein Binding Phospholipase A2 Activator Activity Ubiquitin Binding	Protein Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding K48-linked Polyubiquitin Modification-dependent Protein Binding Ubiquitin Binding ATPase Binding K6-linked Polyubiquitin Modification-dependent Protein Binding Proteasome Regulatory Particle Binding
	Biological Process	Phospholipid Metabolic Process Prostaglandin Metabolic Process Inflammatory Response Signal Transduction Nervous System Development Ubiquitin Recycling Macroautophagy Positive Regulation Of Phospholipase A2 Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Cellular Response To Lipopolysaccharide Negative Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Dendrite Extension Positive Regulation Of Neuron Migration	Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein K48-linked Deubiquitination Negative Regulation Of ERAD Pathway Negative Regulation Of Ubiquitin-specific Protease Activity
Pathways			N-glycan trimming in the ER and Calnexin/Calreticulin cycle Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Drugs
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Metabolite levels ( 23823483) Schizophrenia ( 20185149)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		6 interacting genes: HDAC6 KPNA4 PLA2G1B UBC UBXN1 VCP	20 interacting genes: ACOT7 ACVR1 BARD1 BMPR1B BRCA1 FAM189A2 HMGB1 HOMER2 PLA2G4A PLAA POLR3C RAD23A SMAD1 SMURF1 TGFBR1 TRIM39 UBC UBE2I UBQLN1 UBQLN2
Entrez ID		9373	51035
HPRD ID		04850	11266
Ensembl ID		ENSG00000137055	ENSG00000162191
Uniprot IDs		Q9Y263	A0A024R539 A0A024R598 A0A087WTZ5 Q04323
PDB IDs		2K89 2K8A 2K8B 2K8C 3EBB
Enriched GO Terms of Interacting Partners?
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