CD8A and CD3D

Number of citations of the paper that reports this interaction (PubMedID 12215456)
31

Data Source:
HPRD (in vitro, in vivo)

		CD8A	CD3D
Description		CD8a molecule	CD3d molecule
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane T Cell Receptor Complex Plasma Membrane Raft	Cytoplasm Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Clathrin-coated Endocytic Vesicle Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex
	Molecular Function	Protein Binding Coreceptor Activity MHC Class I Protein Complex Binding MHC Class I Protein Binding	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding
	Biological Process	T Cell Mediated Immunity Immune Response Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Antigen Processing And Presentation T Cell Activation Cytotoxic T Cell Differentiation	Adaptive Immune Response Cell Surface Receptor Signaling Pathway Positive Thymic T Cell Selection
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules PD-1 signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs			Muromonab Blinatumomab
Diseases
GWAS		Blood protein levels ( 30072576)	Pulse pressure ( 27841878)
Interacting Genes		19 interacting genes: B2M CACYBP CD3D CD59 CD8B CDK1 GGCX HLA-A HLA-B HLA-C HLA-E HLA-G LAT LCK LGALS1 MRPS5 PTPRC SREK1 SRSF1	12 interacting genes: AP2M1 CANX CD247 CD3E CD3G CD8A CD8B HERPUD1 KCNA3 SGTB TRA TRB
Entrez ID		925	915
HPRD ID		01737	01730
Ensembl ID		ENSG00000153563	ENSG00000167286
Uniprot IDs		P01732 Q6ZVS2 Q8TAW8	B0YIY4 P04234
PDB IDs		1AKJ 1CD8 1Q69 2HP4 3QZW	1XIW 6JXR
Enriched GO Terms of Interacting Partners?
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