CD3D and TRA

Number of citations of the paper that reports this interaction (PubMedID 8020575)
24

Data Source:
HPRD (in vivo, in vitro)

		CD3D	TRA
Description		CD3d molecule	T cell receptor alpha locus
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Clathrin-coated Endocytic Vesicle Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex	Integral Component Of Membrane Alpha-beta T Cell Receptor Complex
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding	Signaling Receptor Activity
	Biological Process	Adaptive Immune Response Cell Surface Receptor Signaling Pathway Positive Thymic T Cell Selection	Detection Of Tumor Cell T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules PD-1 signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs		Muromonab Blinatumomab
Diseases
GWAS		Pulse pressure ( 27841878)	Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) ( 23648065) Narcolepsy ( 24204295) Periodontal disease-related phenotype (Socransky) ( 26962152)
Interacting Genes		12 interacting genes: AP2M1 CANX CD247 CD3E CD3G CD8A CD8B HERPUD1 KCNA3 SGTB TRA TRB	15 interacting genes: CANX CD247 CD3D CD3G EDEM3 HLA-A HLA-B HLA-DRB1 HSPA5 LEF1 NCOA6 SNTA1 TRAT1 TRB TRD
Entrez ID		915	6955
HPRD ID		01730	01736
Ensembl ID		ENSG00000167286
Uniprot IDs		B0YIY4 P04234
PDB IDs		1XIW 6JXR
Enriched GO Terms of Interacting Partners?
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