CD3D and HERPUD1

Number of citations of the paper that reports this interaction (PubMedID 18307982)
41

Data Source:
HPRD (in vivo)

		CD3D	HERPUD1
Description		CD3d molecule	homocysteine inducible ER protein with ubiquitin like domain 1
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Clathrin-coated Endocytic Vesicle Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Endoplasmic Reticulum Quality Control Compartment Lewy Body Core
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding	Molecular_function Protein Binding Transmembrane Transporter Binding Ubiquitin Ligase-substrate Adaptor Activity
	Biological Process	Adaptive Immune Response Cell Surface Receptor Signaling Pathway Positive Thymic T Cell Selection	Ubiquitin-dependent Protein Catabolic Process Response To Unfolded Protein Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Regulation Of Protein Ubiquitination Endoplasmic Reticulum Calcium Ion Homeostasis Response To Endoplasmic Reticulum Stress Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Targeting To ER Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules PD-1 signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	ATF4 activates genes in response to endoplasmic reticulum stress
Drugs		Muromonab Blinatumomab
Diseases
GWAS		Pulse pressure ( 27841878)	Aspartate aminotransferase levels ( 33547301) Cardiovascular risk factors ( 20838585) Coronary artery disease ( 29212778) Diisocyanate-induced asthma ( 25918132) HDL cholesterol ( 20031564 23505323 24886709) HDL Cholesterol in HIV-infection ( 25884002) HDL cholesterol levels ( 26763881 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels in HIV infection ( 33109212) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 29403010 33339817) Hip circumference adjusted for BMI ( 34021172) Hypo-HDL-cholesterolemia ( 31087446) LDL cholesterol levels ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Low density lipoprotein cholesterol levels ( 33339817) Low HDL-cholesterol levels ( 31910446) Metabolic syndrome ( 20694148) Metabolite levels ( 23823483) Serum metabolite levels ( 33031748) Total cholesterol levels ( 29403010 33339817) Triglyceride levels ( 29403010 33339817) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		12 interacting genes: AP2M1 CANX CD247 CD3E CD3G CD8A CD8B HERPUD1 KCNA3 SGTB TRA TRB	20 interacting genes: AMFR APP ARHGDIA C5AR2 CCR2 CD3D CD58 CHRM2 EWSR1 F2RL1 IMPA2 PSEN1 RPA2 SH3RF1 STARD9 TOLLIP UBQLN2 USP7 VCP XRCC6
Entrez ID		915	9709
HPRD ID		01730	07456
Ensembl ID		ENSG00000167286	ENSG00000051108
Uniprot IDs		B0YIY4 P04234	A4UAE9 Q15011 Q53FP9
PDB IDs		1XIW 6JXR	1WGD
Enriched GO Terms of Interacting Partners?
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