NEK9 and LIN52

		NEK9	LIN52
Description		NIMA related kinase 9	lin-52 DREAM MuvB core complex component
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GO Annotations	Cellular Component	Nucleus Centrosome Cytosol	Nucleoplasm DRM Complex
	Molecular Function	Protein Binding ATP Binding Protein Kinase Binding Metal Ion Binding Protein Serine Kinase Activity	Protein Binding
	Biological Process	Protein Phosphorylation Cell Cycle Cell Division	Transcription, DNA-templated
Pathways		Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Pore Complex (NPC) Disassembly EML4 and NUDC in mitotic spindle formation	Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 Polo-like kinase mediated events Cyclin E associated events during G1/S transition G1/S-Specific Transcription Cyclin A:Cdk2-associated events at S phase entry
Drugs		Fostamatinib
Diseases
GWAS		Coronary artery disease ( 29212778) Feeling fed-up ( 29500382)	Blood protein levels ( 28240269) Chronotype ( 30696823) Macular thickness ( 30535121) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Red cell distribution width ( 32888494) Refractive error ( 32231278) Waist-hip ratio ( 28552196)
Interacting Genes		21 interacting genes: BICD2 CSN2 GABARAP GZMB IFT43 JDP2 LIN52 MALL MAP1LC3B MBP NEK6 NEK7 NEK8 PALS1 RAN RARG RPS6KL1 SSRP1 SUPT16H TTN WDR33	8 interacting genes: DNAL1 DYRK1A EPM2AIP1 MAGEA6 MYBL2 NEK9 RBL2 RPS6KL1
Entrez ID		91754	91750
HPRD ID		11386	18708
Ensembl ID		ENSG00000119638	ENSG00000205659
Uniprot IDs		A0A7I2V454 A0A7I2V5R1 Q6PKF2 Q8TD19	B3KN83 Q52LA3
PDB IDs		3ZKE 3ZKF	4YOO 6C48
Enriched GO Terms of Interacting Partners?
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