LIN52 and MYBL2

Number of citations of the paper that reports this interaction (PubMedID 17671431)
96

Data Source:
BioGRID (pull down, affinity chromatography technology, affinity chromatography technology)

		LIN52	MYBL2
Description		lin-52 DREAM MuvB core complex component	MYB proto-oncogene like 2
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GO Annotations	Cellular Component	Nucleoplasm DRM Complex	Nucleus Nucleoplasm Myb Complex
	Molecular Function	Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Transcription, DNA-templated	Mitotic Cell Cycle Regulation Of Transcription, DNA-templated Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Mitotic Spindle Assembly Cellular Response To Leukemia Inhibitory Factor
Pathways		Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 Polo-like kinase mediated events Cyclin E associated events during G1/S transition G1/S-Specific Transcription Cyclin A:Cdk2-associated events at S phase entry	Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 Polo-like kinase mediated events TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation
Drugs
Diseases
GWAS		Blood protein levels ( 28240269) Chronotype ( 30696823) Macular thickness ( 30535121) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Red cell distribution width ( 32888494) Refractive error ( 32231278) Waist-hip ratio ( 28552196)	Fasting insulin ( 34059833) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		8 interacting genes: DNAL1 DYRK1A EPM2AIP1 MAGEA6 MYBL2 NEK9 RBL2 RPS6KL1	31 interacting genes: CCNA1 CCNA2 CCND1 CCNE1 CCNF CDC34 CDK2 CDK9 CREBBP CXCR4 E2F1 E2F3 EP300 LIN52 LIN9 LZTR1 MAP1LC3B MAPK6 NCOR1 NCOR2 PARP1 RBBP4 RBL1 SKP2 SND1 TRIM15 TTF2 UBB UBE2D4 ZBTB9 ZNF622
Entrez ID		91750	4605
HPRD ID		18708	03247
Ensembl ID		ENSG00000205659	ENSG00000101057
Uniprot IDs		B3KN83 Q52LA3	P10244
PDB IDs		4YOO 6C48	6C48
Enriched GO Terms of Interacting Partners?
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