TRA and HLA-DRB1

Number of citations of the paper that reports this interaction (PubMedID 11877480)
61

Data Source:
BioGRID (x-ray crystallography)
HPRD (in vitro)

		TRA	HLA-DRB1
Description		T cell receptor alpha locus	major histocompatibility complex, class II, DR beta 1
Image		No pdb structure
GO Annotations	Cellular Component	Integral Component Of Membrane Alpha-beta T Cell Receptor Complex	Golgi Membrane Immunological Synapse Extracellular Space Lysosomal Membrane Intermediate Filament Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Late Endosome Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Extracellular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Signaling Receptor Activity	Structural Constituent Of Cytoskeleton Protein Binding MHC Class II Protein Complex Binding Polysaccharide Binding MHC Class II Receptor Activity Peptide Antigen Binding T Cell Receptor Binding CD4 Receptor Binding
	Biological Process	Detection Of Tumor Cell T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Protein Phosphorylation Immunoglobulin Production Involved In Immunoglobulin-mediated Immune Response Inflammatory Response To Antigenic Stimulus Myeloid Dendritic Cell Antigen Processing And Presentation Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class II Peptide Antigen Assembly With MHC Class II Protein Complex Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Negative Regulation Of Inflammatory Response To Antigenic Stimulus Immune Response Humoral Immune Response Cytoskeleton Organization Signal Transduction Epidermis Development Detection Of Bacterium Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Macrophage Differentiation Regulation Of Interleukin-10 Production Regulation Of Interleukin-4 Production Negative Regulation Of Interferon-gamma Production Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Positive Regulation Of Kinase Activity Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus T-helper 1 Type Immune Response Negative Regulation Of T Cell Proliferation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Memory T Cell Differentiation Positive Regulation Of MAPK Cascade Regulation Of T-helper Cell Differentiation Positive Regulation Of Monocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Viral Entry Into Host Cell T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Protein Tetramerization Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation
Pathways			Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling
Drugs			1D09C3 Glatiramer Coccidioides immitis spherule
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) ( 23648065) Narcolepsy ( 24204295) Periodontal disease-related phenotype (Socransky) ( 26962152)	Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Alanine aminotransferase levels ( 33547301) Alzheimer's disease (late onset) ( 30617256 24162737) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Anti-Epstein-Barr virus nuclear antigen (EBNA) IgG levels ( 32737300) Anti-Merkel cell polyomavirus IgG seropositivity ( 33204752) Antisaccade task score ( 31596458) Arterial stiffness index ( 31235810) Arthritis (juvenile idiopathic) ( 18576341) Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 25987655) Aspartate aminotransferase levels ( 33547301 33339817) Asthma ( 31959851 30929738 31619474 29273806) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 26482879) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 29875488) Body mass index ( 28892062) Body shape index ( 34021172) C-reactive protein levels ( 30388399) Cervical cancer ( 23482656 28806749) Childhood ear infection ( 28928442) Childhood onset ulcerative colitis ( 29562276) Childhood steroid-sensitive nephrotic syndrome ( 29903748) Chronic lymphocytic leukemia ( 26956414) Cold sores ( 28928442) Creatinine levels ( 29403010) Crohn's disease ( 23850713 26891255 23266558) Drug-induced liver injury (flucloxacillin) ( 30661239) Enteric fever ( 25383971) Eosinophil counts ( 32888494) Epstein Barr virus nuclear antigen 1 IgG levels ( 26819262 29868224) Epstein-Barr virus immune response (EBNA-1) ( 23326239) Estimated glomerular filtration rate ( 30604766) Extranodal natural killer T-cell lymphoma (nasal type) ( 31879220) Family history of Alzheimer's disease ( 30617256) Giant cell arteritis ( 28041642 25817017) Glomerular filtration rate ( 29403010) Hand grip strength ( 29691431) Heart rate response to exercise ( 29769521) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hepatitis B ( 33736632) Hepatitis B vaccine response ( 24282030) Hepatocellular carcinoma ( 22807686) High density lipoprotein cholesterol levels ( 29403010) Hip circumference adjusted for BMI ( 34021172) Hypothyroidism ( 22493691) IgA nephropathy ( 26028593 25305756 22197929) Immune response to anthrax vaccine ( 22658931) Immunoglobulin A ( 20694011) Immunoglobulin G index levels in multiple sclerosis ( 25616667) Inflammatory bowel disease ( 28067908) Joint damage in rheumatoid arthritis ( 31596875) Lapatinib-induced hepatotoxicity ( 25987243) Late-onset myasthenia gravis ( 26562150) Leishmaniasis (visceral) ( 23291585) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Low hand grip strength (60 years and older) (FNIH) ( 33510174) Lumiracoxib-related liver injury ( 20639878) Lung adenocarcinoma ( 28604730) Lymphocyte counts ( 29403010) Lymphoma ( 23349640) Medication use (immunosuppressants) ( 31015401) Metabolic syndrome ( 31589552) Mixed cellularity Hodgkin lymphoma ( 29196614) Mixed cryoglobulinemia vasculitis in chronic hepatitis C infection ( 25030430) Multiple sclerosis ( 22190364 19525953 19525955 18941528 27386562) Multiple sclerosis (OCB status) ( 23472185) Myasthenia gravis ( 25643325) Myositis ( 26291516) Nephropathy ( 21399633) Neuroblastoma or malignant cutaneous melanoma ( 31605138) Neurofibrillary tangles ( 25188341) Neuromyelitis optica ( 29769526) Neuromyelitis optica (AQP4-IgG-positive) ( 29769526) Nodular sclerosis Hodgkin lymphoma ( 22086417 29196614) Oligoclonal band status in multiple sclerosis ( 25616667) Parental lifespan ( 29030599) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (mother's attained age) ( 29227965) Parkinson's disease ( 32201043) Peanut allergy ( 25710614) PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia ( 30450575) Pemphigus vulgaris ( 29857070) Persistent hepatitis B virus infection ( 33736632) Plantar warts ( 28928442) Pneumonia ( 28928442) Primary biliary cholangitis ( 28062665) Primary biliary cirrhosis ( 22961000) Primary sclerosing cholangitis ( 23603763) Prostate cancer ( 23535732) Red blood cell count ( 32888494) Response to interferon beta therapy ( 21502966) Reticulocyte count ( 27863252) Rheumatoid arthritis ( 25014791 21452313 17804836 32723749 30423114 18794853 17554300 33514426 24390342 20453841 20453842 28118524) Rheumatoid arthritis (ACPA-negative) ( 33514426 24532677) Rheumatoid arthritis (ACPA-positive) ( 33514426) Rheumatoid arthritis (rheumatoid factor and/or anti-cyclic citrullinated peptide seropositive) ( 28118524) Scarlet fever ( 28928442) Schizophrenia ( 23212062) Serum alkaline phosphatase levels ( 33547301) Serum IgE levels ( 25488688) Shingles ( 28928442) SjÃ¶gren's syndrome ( 24097066 28076899) Skin and soft tissue Staphylococcus aureus infection ( 26450422) Small cell lung carcinoma ( 28604730) Staphylococcus aureus infection ( 26450422) Strep throat ( 28928442) Systemic lupus erythematosus ( 24871463 26606652 23273568 32771030 19838193 19838195) Systemic sclerosis ( 30247649 21779181) Takayasu arteritis ( 33308445 25604533 23830517) Thyroid stimulating hormone levels ( 32769997) Tonsillectomy ( 28928442) Total bilirubin levels ( 29403010) Tuberculosis ( 29036319 28928442) Type 1 diabetes ( 17632545) Ulcerative colitis ( 28067908 23128233 21297633 19122664 23511034) Ulcerative colitis or Crohn's disease ( 21699788) Vitiligo ( 27723757) Vogt-Koyanagi-Harada syndrome ( 25108386) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for body mass index ( 34021172 28448500) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Yeast infection ( 28928442)
Interacting Genes		15 interacting genes: CANX CD247 CD3D CD3G EDEM3 HLA-A HLA-B HLA-DRB1 HSPA5 LEF1 NCOA6 SNTA1 TRAT1 TRB TRD	10 interacting genes: CTAG1B HLA-DMA HLA-DRA MAGEA3 MAILR MARCHF1 TRA TRB TRIM21 ZDHHC17
Entrez ID		6955	3123
HPRD ID		01736	08349
Ensembl ID			ENSG00000196126
Uniprot IDs			A0A224MM52 D7RIH8 P01911 Q5Y7D1 X5DNQ0
PDB IDs			1A6A 1AQD 1BX2 1D5M 1D5X 1D5Z 1D6E 1DLH 1FYT 1HXY 1J8H 1JWM 1JWS 1JWU 1KG0 1KLG 1KLU 1LO5 1PYW 1R5I 1SEB 1SJE 1SJH 1T5W 1T5X 1YMM 2FSE 2G9H 2IAM 2IAN 2ICW 2IPK 2OJE 2SEB 2WBJ 2XN9 3L6F 3O6F 3PDO 3PGC 3PGD 3QXA 3QXD 3S4S 3S5L 3T0E 4AEN 4AH2 4C56 4E41 4FQX 4GBX 4I5B 4IS6 4MCY 4MCZ 4MD0 4MD4 4MD5 4MDI 4MDJ 4OV5 4X5W 4X5X 4Y19 4Y1A 5JLZ 5LAX 5NI9 5NIG 6BIJ 6BIL 6BIN 6BIR 6BIV 6BIX 6BIY 6BIZ 6CPL 6CPN 6CPO 6CQJ 6CQL 6CQN 6CQQ 6CQR 6HBY 6NIX 6QZA 6QZC 6QZD 6R0E 6V0Y 6V13 6V15 6V18 6V19 6V1A
Enriched GO Terms of Interacting Partners?
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