HGS and USP54

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		HGS	USP54
Description		hepatocyte growth factor-regulated tyrosine kinase substrate	ubiquitin specific peptidase 54
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Endosome Early Endosome Cytosol Early Endosome Membrane Multivesicular Body Membrane ESCRT-0 Complex Intracellular Membrane-bounded Organelle Extracellular Exosome Phagocytic Vesicle Lumen
	Molecular Function	Protein Binding Protein Domain Specific Binding Phosphatidylinositol Binding Ubiquitin Binding Ubiquitin-like Protein Ligase Binding Metal Ion Binding	Thiol-dependent Deubiquitinase Protein Binding
	Biological Process	Protein Targeting To Lysosome Signal Transduction Negative Regulation Of Cell Population Proliferation Membrane Invagination Positive Regulation Of Gene Expression Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Endosomal Transport Macroautophagy Negative Regulation Of Angiogenesis Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Multivesicular Body Assembly Regulation Of Protein Catabolic Process Regulation Of MAP Kinase Activity Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Protein Localization To Membrane Positive Regulation Of Exosomal Secretion	Protein Deubiquitination
Pathways		EGFR downregulation Lysosome Vesicle Biogenesis Ub-specific processing proteases Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell RHOU GTPase cycle Endosomal Sorting Complex Required For Transport (ESCRT) Inhibition of membrane repair Prevention of phagosomal-lysosomal fusion RHOBTB3 ATPase cycle
Drugs		Citric acid
Diseases
GWAS		Eye color traits ( 20463881) Refractive error ( 32231278)	Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)
Interacting Genes		328 interacting genes: ABI2 ACLY ACOT11 ACTN3 ADRA2C AHCYL1 AKAP8L ANKRD55 ANTKMT APC APLP2 APP ARFIP2 ARL6IP1 ARMC7 ASB12 ATN1 ATP1A1 ATP2A2 ATXN1L BBC3 BCAS2 BEGAIN BFSP2 BICRAL BLOC1S1 BORCS6 BRINP3 BSG C11orf1 C1orf94 C20orf173 C3orf36 C9orf24 CASK CBS CCDC103 CCDC136 CCDC196 CCDC33 CCND3 CDR2 CDSN CEACAM6 CEP55 CEP57L1 CEP63 CEP68 CLTC COG8 CRMP1 CRX CSNK2A1 CSTF2 CSTF2T CTTNBP2NL CYB5R2 DAAM2 DAZAP2 DCTN2 DECR1 DEUP1 DGCR6 DLG4 DSN1 DTX2 DYDC1 EFHC2 EGFL7 EGFR EHMT2 EIF3F EPS15 ESRRG EXOC3L1 EXOC5 EXOC7 EXOC8 EYA2 FAM166A FAM168A FAM185A FANCG FBN1 FCHSD2 FIGN FLOT1 FLOT2 FNDC11 FOXD4L1 FOXI1 FSD2 FTCD GATC GFAP GFI1B GGA2 GKAP1 GOLGA2 GOLGA6L9 GOLGA7B GUCA1C HAP1 HAUS1 HNRNPDL HNRNPM HSF4 HSFY1 HSPA8 ICA1L IFNA16 IFT74 IL2RB IL4R ILKAP ING5 INTS4 IPO4 JAKMIP2 JMJD7 KIAA0753 KIAA0825 KLF4 KRT13 KRT14 KRT15 KRT16 KRT18 KRT19 KRT24 KRT25 KRT26 KRT27 KRT3 KRT31 KRT33B KRT34 KRT35 KRT36 KRT37 KRT38 KRT39 KRT40 KRT6A KRT75 KRT76 KRT82 KRT86 KRTAP19-5 KRTAP26-1 KRTAP7-1 LASP1 LDOC1 LINC00265 LITAF LMO1 LMO4 LRRC61 LURAP1 LYST MAGEB4 MAGED1 MAP3K1 MAP3K10 MAP3K7 MAPK1IP1L MARK4 MAT2A MED21 MED22 MED25 MED30 MED4 MED7 MEIS3 MEST MET METTL27 MIF4GD MKNK1 MKRN3 MRFAP1L1 MTHFD1L NADSYN1 NDC80 NDUFB10 NEDD4 NEDD8 NEFL NF2 NFYC NMI NPAS2 NUP54 NUP62 NUTM2F ODAD1 ODAM OIP5 OSBPL5 P4HA3 PAK1 PAX5 PAX6 PEF1 PELP1 PFKM PIK3R1 PITX1 PKNOX2 PLA2G10 PLAAT1 PLCD1 PLD3 PLEKHB2 PMEPA1 PNMA1 POGZ POU2AF1 POU6F2 PPP1R16A PPP1R32 PPP1R7 PPP2R3B PRR22 PRR5 PSMB11 PSMB4 PTCD3 RASSF4 RBCK1 RFC2 RFX6 RHOBTB3 RINT1 RNF4 RPRD1A RPS3A RSPO4 RSU1 RUNX1 SAPCD1 SCAMP3 SCRN1 SCT SDS SERGEF SERTAD3 SF3B3 SHANK3 SMAD2 SMAD3 SMAD5 SMARCB1 SNAP25 SNX1 SNX5 SNX7 SORBS3 SPATA12 SPC25 SPIRE2 SS18L1 STAM STAM2 STK32C STMN3 STX11 STXBP1 SUMO1 SUN2 SYK TADA2A TASOR2 TBX19 TCP11L2 TEKT1 TEKT5 TFG TIMM10B TIMMDC1 TJP2 TLE5 TMCC2 TOM1L1 TP53BP1 TRAF1 TRAF4 TRAK1 TRAP1 TRIM10 TRIM17 TRIM23 TRIM27 TRIM54 TRIM69 TRIM73 TRIML2 TSC1 TSG101 TUBB TUBB2A UBA1 UBA52 UBAP2 UBB UBC UBE2I UBE4B UBQLN1 UBQLN4 UBQLNL UBXN11 USHBP1 USP54 VGLL3 VMP1 VPS37A VPS37B VPS37C VPS37D VPS52 WASHC1 YPEL3 ZNF302 ZNF34 ZNF430 ZNF44	100 interacting genes: ANKRD11 ANKS1A ARID5B ARMC7 ATN1 ATXN1 ATXN1L ATXN7L2 BFSP2 BHLHE40 CARD10 CCDC13 CCDC24 CCNK CDC23 CDK19 CFAP70 CHCHD2 CHERP CHMP1B CHMP2A CHMP2B CHMP4C COMTD1 CSTF2 CYSRT1 DMRT3 DOK6 DTX2 EIF4E2 EPM2AIP1 EXOC8 FAM124B FAM149B1 FBXO17 FNDC3B FOXI1 FUT11 GCM2 HGS HK1 HNF1B HNRNPF HOXC8 IGFN1 INSC KCTD9 LMO3 LNX1 MED25 MID2 MSS51 MSX2 NUDT22 NXT2 OIP5 OTX1 PCSK5 PHF1 PLA2G6 PLAC8 PLCD1 PLEKHN1 POLR1C PRDM6 PRKAB2 PRR35 QRICH1 RACK1 RAMAC RBPMS2 RHOBTB3 RNF208 SAMD8 SEC24A SHARPIN SHC3 SMARCD1 SMYD1 SNRPB SS18L1 STK16 TBX6 TCEA2 TEKT5 TENT5B TFAP2D TLE5 TNS2 TOLLIP TSEN15 TSSK3 TTC19 TTYH1 UBC USP2 VENTX ZCCHC14 ZNF148 ZNF76
Entrez ID		9146	159195
HPRD ID		05085	15641
Ensembl ID		ENSG00000185359	ENSG00000166348
Uniprot IDs		A0A0S2Z4R4 O14964	B7Z7X1 Q70EL1
PDB IDs		2D3G 3F1I 3OBQ 3ZYQ 4AVX
Enriched GO Terms of Interacting Partners?
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