CD2 and CD5

Number of citations of the paper that reports this interaction (PubMedID 10510361)
6

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		CD2	CD5
Description		CD2 molecule	CD5 molecule
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Cell Surface Protein-containing Complex Membrane Raft Anchored Component Of Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Receptor Tyrosine Kinase Binding Signaling Receptor Activity Identical Protein Binding Protein Self-association	Scavenger Receptor Activity Protein Binding Signaling Receptor Activity
	Biological Process	Membrane Raft Polarization Apoptotic Process Cell Surface Receptor Signaling Pathway Natural Killer Cell Activation Positive Regulation Of Myeloid Dendritic Cell Activation Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion T Cell Activation Regulation Of T Cell Differentiation Cell-cell Adhesion	Endocytosis Cell Recognition T Cell Costimulation Apoptotic Signaling Pathway
Pathways		Cell surface interactions at the vascular wall
Drugs		Alefacept Siplizumab
Diseases
GWAS		Body mass index ( 28552196) Gout (normal type) ( 32238385) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)	Coffee consumption ( 31046077) Gut microbiota (bacterial taxa) ( 27694959) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 24076602 21833088) Rheumatoid arthritis ( 30423114 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		23 interacting genes: CD247 CD2AP CD2BP2 CD4 CD48 CD5 CD53 CD58 CD59 DNAJC5 FYN LCK LGALS1 LINC00311 LYAR MXD1 PSTPIP1 PTPRC RBM15 RHOC SH3KBP1 SP1 UBC	27 interacting genes: CAMK2D CAPN1 CBL CD2 CD247 CD4 CD6 CD72 CD79A CD79B CFL1 CSNK2A1 CTTN DNASE1L2 DYNLT3 FYN HNRNPU LCK MX1 PIK3R1 PRKCA PRKCB PRKCG PTPN6 RASA1 ZAP70 ZNHIT2
Entrez ID		914	921
HPRD ID		01750	01078
Ensembl ID		ENSG00000116824	ENSG00000110448
Uniprot IDs		P06729 Q53F96	P06127
PDB IDs		1CDB 1GYA 1HNF 1L2Z 1QA9 2J6O 2J7I	2JA4 2JOP 2JP0 2OTT
Enriched GO Terms of Interacting Partners?
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