CD2 and RHOC

		CD2	RHOC
Description		CD2 molecule	ras homolog family member C
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Cell Surface Protein-containing Complex Membrane Raft Anchored Component Of Plasma Membrane	Nucleus Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Plasma Membrane Cell Cortex Cytoplasmic Vesicle Cleavage Furrow Stereocilium Cell Projection Neuron Projection Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Protein Binding Receptor Tyrosine Kinase Binding Signaling Receptor Activity Identical Protein Binding Protein Self-association	GTPase Activity Protein Binding GTP Binding Protein Kinase Binding
	Biological Process	Membrane Raft Polarization Apoptotic Process Cell Surface Receptor Signaling Pathway Natural Killer Cell Activation Positive Regulation Of Myeloid Dendritic Cell Activation Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion T Cell Activation Regulation Of T Cell Differentiation Cell-cell Adhesion	Mitotic Cytokinesis Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Small GTPase Mediated Signal Transduction Regulation Of Cell Shape Cell Migration Positive Regulation Of Cell Migration Cortical Cytoskeleton Organization Positive Regulation Of Protein-containing Complex Assembly Regulation Of Actin Cytoskeleton Organization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apical Junction Assembly Wound Healing, Spreading Of Cells Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Lipase Activity Skeletal Muscle Satellite Cell Migration
Pathways		Cell surface interactions at the vascular wall	G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases Activate ROCKs RHO GTPases Activate Formins RHO GTPases Activate Rhotekin and Rhophilins RHOC GTPase cycle
Drugs		Alefacept Siplizumab
Diseases
GWAS		Body mass index ( 28552196) Gout (normal type) ( 32238385) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical surface area (visual PC2) ( 32198502) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate (creatinine) ( 28452372) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		23 interacting genes: CD247 CD2AP CD2BP2 CD4 CD48 CD5 CD53 CD58 CD59 DNAJC5 FYN LCK LGALS1 LINC00311 LYAR MXD1 PSTPIP1 PTPRC RBM15 RHOC SH3KBP1 SP1 UBC	10 interacting genes: ARHGAP1 CAV1 CD2 CIT DIAPH1 PIK3CA RIPOR2 RIPOR3 ROCK1 RTKN
Entrez ID		914	389
HPRD ID		01750	01322
Ensembl ID		ENSG00000116824	ENSG00000155366
Uniprot IDs		P06729 Q53F96	A0A024R0C8 P08134
PDB IDs		1CDB 1GYA 1HNF 1L2Z 1QA9 2J6O 2J7I	1Z2C 2GCN 2GCO 2GCP
Enriched GO Terms of Interacting Partners?
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