CD2 and LYAR

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		CD2	LYAR
Description		CD2 molecule	Ly1 antibody reactive
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Cell Surface Protein-containing Complex Membrane Raft Anchored Component Of Plasma Membrane	Photoreceptor Outer Segment Nucleus Nucleoplasm Nucleolus Cytoplasm
	Molecular Function	Signaling Receptor Binding Protein Binding Receptor Tyrosine Kinase Binding Signaling Receptor Activity Identical Protein Binding Protein Self-association	DNA Binding RNA Binding Protein Binding Identical Protein Binding Metal Ion Binding DNA-binding Transcription Factor Binding Transcription Regulator Inhibitor Activity
	Biological Process	Membrane Raft Polarization Apoptotic Process Cell Surface Receptor Signaling Pathway Natural Killer Cell Activation Positive Regulation Of Myeloid Dendritic Cell Activation Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion T Cell Activation Regulation Of T Cell Differentiation Cell-cell Adhesion	Negative Regulation Of Transcription By RNA Polymerase II RRNA Processing Innate Immune Response Negative Regulation Of Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase I Erythrocyte Development Positive Regulation Of Phagocytosis
Pathways		Cell surface interactions at the vascular wall
Drugs		Alefacept Siplizumab
Diseases
GWAS		Body mass index ( 28552196) Gout (normal type) ( 32238385) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)	Disease progression in age-related macular degeneration ( 29346644)
Interacting Genes		23 interacting genes: CD247 CD2AP CD2BP2 CD4 CD48 CD5 CD53 CD58 CD59 DNAJC5 FYN LCK LGALS1 LINC00311 LYAR MXD1 PSTPIP1 PTPRC RBM15 RHOC SH3KBP1 SP1 UBC	14 interacting genes: ADSS1 BEND7 CD2 FGF18 GSK3B OGT PHF20L1 PRKRA SDCBP2 SREK1IP1 TERF1 TERF2 ZBTB16 ZHX1
Entrez ID		914	55646
HPRD ID		01750	10064
Ensembl ID		ENSG00000116824	ENSG00000145220
Uniprot IDs		P06729 Q53F96	Q9NX58
PDB IDs		1CDB 1GYA 1HNF 1L2Z 1QA9 2J6O 2J7I	6ZMI 6ZMO 6ZVH
Enriched GO Terms of Interacting Partners?
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