SPSB3 and NUMBL

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid, two hybrid)

		SPSB3	NUMBL
Description		splA/ryanodine receptor domain and SOCS box containing 3	NUMB like endocytic adaptor protein
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol SCF Ubiquitin Ligase Complex	Cytoplasm
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Nervous System Development Axonogenesis Cytokine-mediated Signaling Pathway Protein Metabolic Process Lateral Ventricle Development Neuroblast Division In Subventricular Zone Adherens Junction Organization Positive Regulation Of Neurogenesis
Pathways		Neddylation
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Plateletcrit ( 32888494) PR interval ( 32439900)	Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) level) ( 27702941) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941) Caffeine metabolism (plasma 3,7-dimethylxanthine (theobromine) level) ( 27702941) Carotid intima media thickness (mean) ( 31801372) Kawasaki disease ( 22446962) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730)
Interacting Genes		5 interacting genes: CSNK2B ENKD1 MAPK8IP2 NUMBL ZNF396	24 interacting genes: ACTN1 APP ATXN1 BHLHE40 EGFR EPS15 ESRP2 GAA GPATCH8 GRIP1 MAGED1 NOTCH1 PSMA3 RBFOX1 RIPK1 SIAH1 SPSB3 TAB2 THPO TMC5 TRAF5 TRAF6 UBE3A YWHAG
Entrez ID		90864	9253
HPRD ID		18107	04931
Ensembl ID		ENSG00000162032	ENSG00000105245
Uniprot IDs		Q6PJ21	A0A0C4DGH3 A8K033 B7Z5W0 Q9Y6R0
PDB IDs			3F0W
Enriched GO Terms of Interacting Partners?
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