NUMBL and TMC5

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		NUMBL	TMC5
Description		NUMB like endocytic adaptor protein	transmembrane channel like 5
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Integral Component Of Plasma Membrane Extracellular Exosome
	Molecular Function	Protein Binding	Mechanosensitive Ion Channel Activity
	Biological Process	Nervous System Development Axonogenesis Cytokine-mediated Signaling Pathway Protein Metabolic Process Lateral Ventricle Development Neuroblast Division In Subventricular Zone Adherens Junction Organization Positive Regulation Of Neurogenesis	Ion Transmembrane Transport
Pathways
Drugs
Diseases
GWAS		Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) level) ( 27702941) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941) Caffeine metabolism (plasma 3,7-dimethylxanthine (theobromine) level) ( 27702941) Carotid intima media thickness (mean) ( 31801372) Kawasaki disease ( 22446962) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730)	Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) HDL cholesterol ( 31170924) Nicotine dependence symptom count ( 25555482) Parkinson's disease motor subtype (tremor dominant vs postural instability/gait difficulty) ( 33987465) Sleep duration ( 23728906)
Interacting Genes		24 interacting genes: ACTN1 APP ATXN1 BHLHE40 EGFR EPS15 ESRP2 GAA GPATCH8 GRIP1 MAGED1 NOTCH1 PSMA3 RBFOX1 RIPK1 SIAH1 SPSB3 TAB2 THPO TMC5 TRAF5 TRAF6 UBE3A YWHAG	1 interacting genes: NUMBL
Entrez ID		9253	79838
HPRD ID		04931	15516
Ensembl ID		ENSG00000105245	ENSG00000103534
Uniprot IDs		A0A0C4DGH3 A8K033 B7Z5W0 Q9Y6R0	B7Z5K3 B7Z946 F5GYU8 Q6UXY8
PDB IDs		3F0W
Enriched GO Terms of Interacting Partners?
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