NUMBL and THPO

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		NUMBL	THPO
Description		NUMB like endocytic adaptor protein	thrombopoietin
Image
GO Annotations	Cellular Component	Cytoplasm	Extracellular Region Extracellular Space
	Molecular Function	Protein Binding	Signaling Receptor Binding Cytokine Activity Hormone Activity Growth Factor Activity
	Biological Process	Nervous System Development Axonogenesis Cytokine-mediated Signaling Pathway Protein Metabolic Process Lateral Ventricle Development Neuroblast Division In Subventricular Zone Adherens Junction Organization Positive Regulation Of Neurogenesis	Positive Regulation Of Protein Phosphorylation Multicellular Organism Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Megakaryocyte Development Thrombopoietin-mediated Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Megakaryocyte Differentiation Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of ERK1 And ERK2 Cascade Receptor Signaling Pathway Via STAT Positive Regulation Of Hematopoietic Stem Cell Proliferation
Pathways			Platelet Aggregation (Plug Formation)
Drugs
Diseases
GWAS		Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) level) ( 27702941) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941) Caffeine metabolism (plasma 3,7-dimethylxanthine (theobromine) level) ( 27702941) Carotid intima media thickness (mean) ( 31801372) Kawasaki disease ( 22446962) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730)	Cardiometabolic and hematological traits ( 27668658) Diisocyanate-induced asthma ( 25918132) Mean spheric corpuscular volume ( 32888494) Platelet count ( 22139419 29403010 32888494 20139978 27863252) Plateletcrit ( 32888494 27863252)
Interacting Genes		24 interacting genes: ACTN1 APP ATXN1 BHLHE40 EGFR EPS15 ESRP2 GAA GPATCH8 GRIP1 MAGED1 NOTCH1 PSMA3 RBFOX1 RIPK1 SIAH1 SPSB3 TAB2 THPO TMC5 TRAF5 TRAF6 UBE3A YWHAG	4 interacting genes: APH1A EP300 MPL NUMBL
Entrez ID		9253	7066
HPRD ID		04931	02500
Ensembl ID		ENSG00000105245	ENSG00000090534
Uniprot IDs		A0A0C4DGH3 A8K033 B7Z5W0 Q9Y6R0	A0A3B3ITS0 F8W6L1 P40225 Q5FBX8
PDB IDs		3F0W	1V7M 1V7N
Enriched GO Terms of Interacting Partners?
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