ASH2L and KMT2D

Number of citations of the paper that reports this interaction (PubMedID 16603732)
79

Data Source:
BioGRID (proximity labelling technology)
HPRD (in vitro)

		ASH2L	KMT2D
Description		ASH2 like, histone lysine methyltransferase complex subunit	lysine methyltransferase 2D
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex MLL3/4 Complex Set1C/COMPASS Complex	Nucleus Nucleoplasm Histone Methyltransferase Complex MLL3/4 Complex
	Molecular Function	Transcription Cis-regulatory Region Binding Protein Binding Beta-catenin Binding Histone Methyltransferase Activity (H3-K4 Specific) Metal Ion Binding	Transcription Cis-regulatory Region Binding DNA Binding Transcription Coactivator Activity Protein Binding Histone Binding Histone Methyltransferase Activity (H3-K4 Specific) Metal Ion Binding
	Biological Process	Cellular Response To DNA Damage Stimulus Positive Regulation Of Cell Population Proliferation Hemopoiesis Response To Estrogen Histone H3-K4 Methylation	Oocyte Growth Regulation Of Transcription, DNA-templated Positive Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Response To Estrogen Histone H3-K4 Dimethylation Positive Regulation Of Transcription By RNA Polymerase II Oogenesis Histone H3-K4 Methylation Histone H3-K4 Trimethylation Histone H3-K4 Monomethylation Beta-catenin-TCF Complex Assembly
Pathways		Formation of the beta-catenin:TCF transactivating complex PKMTs methylate histone lysines Deactivation of the beta-catenin transactivating complex Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	Formation of the beta-catenin:TCF transactivating complex PKMTs methylate histone lysines Deactivation of the beta-catenin transactivating complex Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS		Menopause (age at onset) ( 22267201) Schizophrenia ( 29483656) Venous thromboembolism ( 33592630)	Chronotype ( 30696823) General cognitive ability ( 29844566) HDL cholesterol levels in HIV infection ( 33109212) Heel bone mineral density ( 30598549) Intelligence (MTAG) ( 29326435)
Interacting Genes		37 interacting genes: ACTC1 ACTN2 ANKRD1 ATP1A3 BARD1 BRCA1 CCNC CEP76 CHD8 COPS6 CTNNB1 DNMT3L DPY30 EP300 FURIN H3-4 H3C1 KMT2A KMT2B KMT2D KMT2E MEN1 MESD MKRN1 MYBPC1 MYOM3 PPP1CC PRMT1 SMAD9 SMURF1 SMURF2 TGFBR1 TP53 TTN UNC119 WWP1 ZSCAN1	13 interacting genes: AKT1 ASH2L CTNNB1 ESR1 FBXW7 H3C14 H4C1 MEN1 POLR2A SHMT2 SMAD1 SMAD9 TUBA1C
Entrez ID		9070	8085
HPRD ID		05309	03664
Ensembl ID		ENSG00000129691	ENSG00000167548
Uniprot IDs		B4DPT1 F5H8F7 Q9UBL3	O14686 Q59FG6 Q6PIA1
PDB IDs		3RSN 3S32 3TOJ 4RIQ 4X8N 4X8P 5F6K 5F6L 6E2H 6KIU 6KIV 6KIW 6KIX 6KIZ 6PWV 7BRE	3UVK 4ERQ 4Z4P 6O7G
Enriched GO Terms of Interacting Partners?
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