KMT2D

Description		lysine methyltransferase 2D
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex MLL3/4 Complex
	Molecular Function	Transcription Cis-regulatory Region Binding DNA Binding Transcription Coactivator Activity Protein Binding Histone Binding Histone Methyltransferase Activity (H3-K4 Specific) Metal Ion Binding
	Biological Process	Oocyte Growth Regulation Of Transcription, DNA-templated Positive Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Response To Estrogen Histone H3-K4 Dimethylation Positive Regulation Of Transcription By RNA Polymerase II Oogenesis Histone H3-K4 Methylation Histone H3-K4 Trimethylation Histone H3-K4 Monomethylation Beta-catenin-TCF Complex Assembly
Pathways		Formation of the beta-catenin:TCF transactivating complex PKMTs methylate histone lysines Deactivation of the beta-catenin transactivating complex Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
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Diseases
GWAS		Chronotype ( 30696823) General cognitive ability ( 29844566) HDL cholesterol levels in HIV infection ( 33109212) Heel bone mineral density ( 30598549) Intelligence (MTAG) ( 29326435)
Interacting Genes		13 interacting genes: AKT1 ASH2L CTNNB1 ESR1 FBXW7 H3C14 H4C1 MEN1 POLR2A SHMT2 SMAD1 SMAD9 TUBA1C
Entrez ID		8085
HPRD ID		03664
Ensembl ID		ENSG00000167548
Uniprot IDs		O14686 Q59FG6 Q6PIA1
PDB IDs		3UVK 4ERQ 4Z4P 6O7G
Enriched GO Terms of Interacting Partners?
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