ASH2L and SMAD9

Number of citations of the paper that reports this interaction (PubMedID 15231748)
99

Data Source:
HPRD (two hybrid)

		ASH2L	SMAD9
Description		ASH2 like, histone lysine methyltransferase complex subunit	SMAD family member 9
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex MLL3/4 Complex Set1C/COMPASS Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol SMAD Protein Complex Heteromeric SMAD Protein Complex
	Molecular Function	Transcription Cis-regulatory Region Binding Protein Binding Beta-catenin Binding Histone Methyltransferase Activity (H3-K4 Specific) Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding I-SMAD Binding
	Biological Process	Cellular Response To DNA Damage Stimulus Positive Regulation Of Cell Population Proliferation Hemopoiesis Response To Estrogen Histone H3-K4 Methylation	Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Anatomical Structure Morphogenesis Cell Differentiation BMP Signaling Pathway SMAD Protein Signal Transduction Cellular Response To BMP Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus
Pathways		Formation of the beta-catenin:TCF transactivating complex PKMTs methylate histone lysines Deactivation of the beta-catenin transactivating complex Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	Signaling by BMP
Drugs
Diseases
GWAS		Menopause (age at onset) ( 22267201) Schizophrenia ( 29483656) Venous thromboembolism ( 33592630)	Coronary artery disease ( 29212778) Heel bone mineral density ( 30598549 28869591) Perioperative myocardial infarction in coronary artery bypass surgery ( 25948407) Spontaneous preterm birth (preterm birth) ( 25599974) Total body bone mineral density ( 29304378)
Interacting Genes		37 interacting genes: ACTC1 ACTN2 ANKRD1 ATP1A3 BARD1 BRCA1 CCNC CEP76 CHD8 COPS6 CTNNB1 DNMT3L DPY30 EP300 FURIN H3-4 H3C1 KMT2A KMT2B KMT2D KMT2E MEN1 MESD MKRN1 MYBPC1 MYOM3 PPP1CC PRMT1 SMAD9 SMURF1 SMURF2 TGFBR1 TP53 TTN UNC119 WWP1 ZSCAN1	117 interacting genes: ABTB1 ACTB ACVR1 AFF1 AP2A1 ARHGAP9 ARID1B ARNT ASB2 ASH2L BAZ1A BTG2 CAMSAP1 CEP135 CHPF CLPB CPXM2 CSH1 CSH2 CTR9 CXXC5 CYP11A1 DIAPH3 DKK1 DNAJA3 DNAJC7 DST DSTN E4F1 EIF3C EIF3E EIF3F ERVV-1 EVC2 EXPH5 FLI1 FN1 FTL GRN HEY1 HEYL HUWE1 KDM1A KDM6A KMT2D LEMD3 LMO4 LNPEP LRP5 MACO1 MAN1A2 MAN1C1 MAN2B1 MBD1 MCM3AP METAP1 MGAT1 MTMR10 MTMR11 NAGK OTUB1 PABPC4 PAPPA PELP1 PHKA2 PIR PKP2 PLEC PNPLA2 PPARD PPP2R5E PRMT6 PSAP PSMD8 QARS1 RANBP9 RFX1 RMND5A RNF123 RRBP1 RUBCN SECISBP2 SF3B1 SIL1 SMAD2 SMAD3 SMAD4 SMG1 SNRNP70 SPTBN1 STAG1 SVEP1 TBCD TERF1 TINAGL1 TOB1 TRIM29 TRIP12 TTC37 TWNK UBA6 UBE3A UBQLN1 UBQLN4 UNC45A VCPIP1 VPS8 XAB2 YWHAQ ZEB2 ZNF484 ZNF557 ZNF587 ZNF587B ZNF592 ZNF83 ZSCAN4
Entrez ID		9070	4093
HPRD ID		05309	04484
Ensembl ID		ENSG00000129691	ENSG00000120693
Uniprot IDs		B4DPT1 F5H8F7 Q9UBL3	A0A024RDR3 O15198
PDB IDs		3RSN 3S32 3TOJ 4RIQ 4X8N 4X8P 5F6K 5F6L 6E2H 6KIU 6KIV 6KIW 6KIX 6KIZ 6PWV 7BRE	6FZT
Enriched GO Terms of Interacting Partners?
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