ASH2L

Description		ASH2 like, histone lysine methyltransferase complex subunit
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex MLL3/4 Complex Set1C/COMPASS Complex
	Molecular Function	Transcription Cis-regulatory Region Binding Protein Binding Beta-catenin Binding Histone Methyltransferase Activity (H3-K4 Specific) Metal Ion Binding
	Biological Process	Cellular Response To DNA Damage Stimulus Positive Regulation Of Cell Population Proliferation Hemopoiesis Response To Estrogen Histone H3-K4 Methylation
Pathways		Formation of the beta-catenin:TCF transactivating complex PKMTs methylate histone lysines Deactivation of the beta-catenin transactivating complex Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS		Menopause (age at onset) ( 22267201) Schizophrenia ( 29483656) Venous thromboembolism ( 33592630)
Interacting Genes		37 interacting genes: ACTC1 ACTN2 ANKRD1 ATP1A3 BARD1 BRCA1 CCNC CEP76 CHD8 COPS6 CTNNB1 DNMT3L DPY30 EP300 FURIN H3-4 H3C1 KMT2A KMT2B KMT2D KMT2E MEN1 MESD MKRN1 MYBPC1 MYOM3 PPP1CC PRMT1 SMAD9 SMURF1 SMURF2 TGFBR1 TP53 TTN UNC119 WWP1 ZSCAN1
Entrez ID		9070
HPRD ID		05309
Ensembl ID		ENSG00000129691
Uniprot IDs		B4DPT1 F5H8F7 Q9UBL3
PDB IDs		3RSN 3S32 3TOJ 4RIQ 4X8N 4X8P 5F6K 5F6L 6E2H 6KIU 6KIV 6KIW 6KIX 6KIZ 6PWV 7BRE
Enriched GO Terms of Interacting Partners?
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