TNKS and TNKS2

Number of citations of the paper that reports this interaction (PubMedID 11802774)
45

Data Source:
HPRD (in vitro, in vivo)

		TNKS	TNKS2
Description		tankyrase	tankyrase 2
Image
GO Annotations	Cellular Component	Golgi Membrane Pericentriolar Material Chromosome, Telomeric Region Nucleus Nuclear Pore Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Nuclear Body Nuclear Membrane Mitotic Spindle Pole	Golgi Membrane Pericentriolar Material Chromosome, Telomeric Region Nucleus Nuclear Envelope Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	NAD+ ADP-ribosyltransferase Activity Protein Binding Zinc Ion Binding Histone Binding Protein ADP-ribosylase Activity	NAD+ ADP-ribosyltransferase Activity Protein Binding Enzyme Binding Metal Ion Binding Protein ADP-ribosylase Activity
	Biological Process	Protein Polyubiquitination Protein ADP-ribosylation Mitotic Spindle Organization Protein Transport Wnt Signaling Pathway Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cellular Response To Nutrient Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Transcription By RNA Polymerase II MRNA Transport Spindle Assembly Cell Division Positive Regulation Of Telomerase Activity Protein Localization To Chromosome, Telomeric Region Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomeric DNA Binding Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Telomeric	Protein Polyubiquitination Protein ADP-ribosylation Wnt Signaling Pathway Positive Regulation Of Telomere Maintenance Via Telomerase Multicellular Organism Growth Regulation Of Multicellular Organism Growth Protein Localization To Chromosome, Telomeric Region Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Pathways		TCF dependent signaling in response to WNT Degradation of AXIN XAV939 stabilizes AXIN Ub-specific processing proteases Regulation of PTEN stability and activity	TCF dependent signaling in response to WNT Degradation of AXIN XAV939 stabilizes AXIN Ub-specific processing proteases Regulation of PTEN stability and activity
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Age at first birth ( 34211149) Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 34315874) Bipolar disorder ( 31043756) Body shape index ( 34021172) Bone mineral density (Ward's triangle area) ( 27397699) Brain morphology (MOSTest) ( 32665545) Cataracts (operation) ( 31816047) Deep white matter hyperintensities ( 32517579) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Fish- and plant-related diet ( 32066663) General risk tolerance (MTAG) ( 30643258) Joint mobility (Beighton score) ( 27182965) LDL cholesterol levels ( 32203549) Metabolite levels ( 22916037) Mosquito bite size ( 28199695) Nose size ( 27182965) Obesity (early onset extreme) ( 20421936) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Refractive error ( 32231278) Regular attendance at a religious group ( 29970889) Response to inhaled corticosteroid treatment in asthma (change in FEV1) ( 24792382) Response to radiotherapy in nasopharyngeal carcinoma (acute oral mucositis) ( 32503578) Schizophrenia ( 26198764) Serum alkaline phosphatase levels ( 33547301) Systemic lupus erythematosus ( 28714469) Systolic blood pressure ( 30224653) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Triglyceride levels ( 32154731) Type 2 diabetes ( 30054458) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)	Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver volume ( 34128465) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		25 interacting genes: ADPRS ANKRD28 BABAM1 DISC1 EIF4A1 EPM2AIP1 FANCD2 FNBP1 LNPEP MCL1 NELFE NUMA1 OARD1 POT1 PTEN SDCBP SH3BP5 TCL1A TERF1 TNIK TNKS1BP1 TNKS2 UBASH3B USP25 VPS33A	14 interacting genes: AMOTL2 ANKRD28 ARAP3 GRB14 LNPEP MAPK1 MDC1 PTEN SASH1 SH3BP2 TERF1 TNKS TNKS1BP1 ZNF512B
Entrez ID		8658	80351
HPRD ID		04490	06182
Ensembl ID		ENSG00000173273	ENSG00000107854
Uniprot IDs		O95271	Q9H2K2
PDB IDs		2RF5 3UDD 3UH2 3UH4 4DVI 4I9I 4K4E 4K4F 4KRS 4LI6 4LI7 4LI8 4MSG 4MSK 4MT9 4N3R 4N4V 4OA7 4TOR 4TOS 4U6A 4UUH 4UW1 4W5S 4W6E 5EBT 5ECE 5ETY 5GP7 5JHQ 5JTI 5JU5 5KNI 6QXU 6URQ	2Y0I 3KR7 3KR8 3MHJ 3MHK 3P0N 3P0P 3P0Q 3TWQ 3TWR 3TWS 3TWT 3TWU 3TWV 3TWW 3TWX 3U9H 3U9Y 3UA9 3W51 4AVU 4AVW 4BFP 4BJ9 4BJB 4BJC 4BS4 4BU3 4BU5 4BU6 4BU7 4BU8 4BU9 4BUA 4BUD 4BUE 4BUF 4BUI 4BUS 4BUT 4BUU 4BUV 4BUW 4BUX 4BUY 4HKI 4HKK 4HKN 4HL5 4HLF 4HLG 4HLH 4HLK 4HLM 4HMH 4HYF 4IUE 4J1Z 4J21 4J22 4J3L 4J3M 4KZL 4KZQ 4KZU 4L09 4L0B 4L0I 4L0S 4L0T 4L0V 4L10 4L2F 4L2G 4L2K 4L31 4L32 4L33 4L34 4M7B 4PML 4PNL 4PNM 4PNN 4PNQ 4PNR 4PNS 4PNT 4TJU 4TJW 4TJY 4TK0 4TK5 4TKF 4TKG 4TKI 4UFU 4UFY 4UHG 4UI3 4UI4 4UI5 4UI6 4UI7 4UI8 4UVL 4UVN 4UVO 4UVP 4UVS 4UVT 4UVU 4UVV 4UVW 4UVX 4UVY 4UVZ 4UX4 4W5I 4Z68 5ADQ 5ADR 5ADS 5ADT 5AEH 5AKU 5AKW 5AL1 5AL2 5AL3 5AL4 5AL5 5BXO 5BXU 5C5P 5C5Q 5C5R 5DCZ 5FPF 5FPG 5JRT 5NOB 5NSP 5NUT 5OWS 5OWT 6TG4 6TKM 6TKN 6TKP 6TKQ 6TKR 6TKS
Enriched GO Terms of Interacting Partners?
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