TNKS and FANCD2

  • Number of citations of the paper that reports this interaction (PubMedID 21314979)
  • 9
  • Data Source:
  • BioGRID (pull down, enzymatic study)

TNKS

FANCD2

Description tankyrase FA complementation group D2
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Acne (severe) ( 24927181)
  • Age at first birth ( 34211149)
  • Alanine aminotransferase levels ( 33547301 34315874)
  • Aspartate aminotransferase levels ( 34315874)
  • Bipolar disorder ( 31043756)
  • Body shape index ( 34021172)
  • Bone mineral density (Ward's triangle area) ( 27397699)
  • Brain morphology (MOSTest) ( 32665545)
  • Cataracts (operation) ( 31816047)
  • Deep white matter hyperintensities ( 32517579)
  • Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
  • Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858)
  • Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
  • Fish- and plant-related diet ( 32066663)
  • General risk tolerance (MTAG) ( 30643258)
  • Joint mobility (Beighton score) ( 27182965)
  • LDL cholesterol levels ( 32203549)
  • Metabolite levels ( 22916037)
  • Mosquito bite size ( 28199695)
  • Nose size ( 27182965)
  • Obesity (early onset extreme) ( 20421936)
  • Oily fish consumption ( 32066663)
  • Pork consumption ( 32066663)
  • Pulse pressure x alcohol consumption interaction (2df test) ( 29912962)
  • Refractive error ( 32231278)
  • Regular attendance at a religious group ( 29970889)
  • Response to inhaled corticosteroid treatment in asthma (change in FEV1) ( 24792382)
  • Response to radiotherapy in nasopharyngeal carcinoma (acute oral mucositis) ( 32503578)
  • Schizophrenia ( 26198764)
  • Serum alkaline phosphatase levels ( 33547301)
  • Systemic lupus erythematosus ( 28714469)
  • Systolic blood pressure ( 30224653)
  • Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
  • Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858)
  • Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
  • Triglyceride levels ( 32154731)
  • Type 2 diabetes ( 30054458)
  • Waist circumference adjusted for body mass index ( 34021172)
  • Waist-hip index ( 34021172)
  • Waist-to-hip ratio adjusted for BMI ( 34021172)
  • White matter hyperintensity volume ( 33293549)
  • White matter hyperintensity volume (adjusted for hypertension) ( 33293549)
  • White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
  • Alzheimer's disease ( 24755620)
  • Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes 25 interacting genes: ADPRS ANKRD28 BABAM1 DISC1 EIF4A1 EPM2AIP1 FANCD2 FNBP1 LNPEP MCL1 NELFE NUMA1 OARD1 POT1 PTEN SDCBP SH3BP5 TCL1A TERF1 TNIK TNKS1BP1 TNKS2 UBASH3B USP25 VPS33A 30 interacting genes: ATM ATR BLM BRCA1 BRCA2 BRIP1 FANCC FANCE FANCI FANCL H2AC4 H2BC3 H3C1 H4C1 MEN1 MRE11 NBN PCNA RAD51 TERF1 TNFRSF1A TNFRSF1B TNKS UBB UBE2T UHRF1 UHRF2 USP1 USP2 USP7
Entrez ID 8658 2177
HPRD ID 04490 01968
Ensembl ID ENSG00000173273 ENSG00000144554
Uniprot IDs O95271 Q9BXW9
PDB IDs 2RF5 3UDD 3UH2 3UH4 4DVI 4I9I 4K4E 4K4F 4KRS 4LI6 4LI7 4LI8 4MSG 4MSK 4MT9 4N3R 4N4V 4OA7 4TOR 4TOS 4U6A 4UUH 4UW1 4W5S 4W6E 5EBT 5ECE 5ETY 5GP7 5JHQ 5JTI 5JU5 5KNI 6QXU 6URQ 6VAA 6VAD 6VAE 6VAF
Enriched GO Terms of Interacting Partners?
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