TNKS and SDCBP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TNKS	SDCBP
Description		tankyrase	syndecan binding protein
Image
GO Annotations	Cellular Component	Golgi Membrane Pericentriolar Material Chromosome, Telomeric Region Nucleus Nuclear Pore Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Nuclear Body Nuclear Membrane Mitotic Spindle Pole	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Plasma Membrane Interleukin-5 Receptor Complex Adherens Junction Focal Adhesion Membrane Nuclear Membrane Azurophil Granule Lumen Melanosome Membrane Raft Synapse Extracellular Exosome Blood Microparticle Extracellular Vesicle
	Molecular Function	NAD+ ADP-ribosyltransferase Activity Protein Binding Zinc Ion Binding Histone Binding Protein ADP-ribosylase Activity	Frizzled Binding Interleukin-5 Receptor Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Protein C-terminus Binding Cytoskeletal Anchor Activity Growth Factor Binding Neurexin Family Protein Binding Identical Protein Binding Protein-containing Complex Binding Syndecan Binding Ephrin Receptor Binding Protein Heterodimerization Activity Protein N-terminus Binding Cell Adhesion Molecule Binding
	Biological Process	Protein Polyubiquitination Protein ADP-ribosylation Mitotic Spindle Organization Protein Transport Wnt Signaling Pathway Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cellular Response To Nutrient Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Transcription By RNA Polymerase II MRNA Transport Spindle Assembly Cell Division Positive Regulation Of Telomerase Activity Protein Localization To Chromosome, Telomeric Region Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomeric DNA Binding Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Telomeric	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Receptor Internalization Protein Targeting To Membrane Substrate-dependent Cell Migration, Cell Extension Ras Protein Signal Transduction Chemical Synaptic Transmission Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Actin Cytoskeleton Organization Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of JNK Cascade Presynapse Assembly Positive Regulation Of Exosomal Secretion Positive Regulation Of Extracellular Exosome Assembly
Pathways		TCF dependent signaling in response to WNT Degradation of AXIN XAV939 stabilizes AXIN Ub-specific processing proteases Regulation of PTEN stability and activity	Ephrin signaling Neurofascin interactions RIPK1-mediated regulated necrosis Regulation of necroptotic cell death Neutrophil degranulation
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Age at first birth ( 34211149) Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 34315874) Bipolar disorder ( 31043756) Body shape index ( 34021172) Bone mineral density (Ward's triangle area) ( 27397699) Brain morphology (MOSTest) ( 32665545) Cataracts (operation) ( 31816047) Deep white matter hyperintensities ( 32517579) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Fish- and plant-related diet ( 32066663) General risk tolerance (MTAG) ( 30643258) Joint mobility (Beighton score) ( 27182965) LDL cholesterol levels ( 32203549) Metabolite levels ( 22916037) Mosquito bite size ( 28199695) Nose size ( 27182965) Obesity (early onset extreme) ( 20421936) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Refractive error ( 32231278) Regular attendance at a religious group ( 29970889) Response to inhaled corticosteroid treatment in asthma (change in FEV1) ( 24792382) Response to radiotherapy in nasopharyngeal carcinoma (acute oral mucositis) ( 32503578) Schizophrenia ( 26198764) Serum alkaline phosphatase levels ( 33547301) Systemic lupus erythematosus ( 28714469) Systolic blood pressure ( 30224653) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Triglyceride levels ( 32154731) Type 2 diabetes ( 30054458) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)	Aspartate aminotransferase levels ( 33547301) Fasting insulin ( 34074324) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Triglyceride levels ( 32154731)
Interacting Genes		25 interacting genes: ADPRS ANKRD28 BABAM1 DISC1 EIF4A1 EPM2AIP1 FANCD2 FNBP1 LNPEP MCL1 NELFE NUMA1 OARD1 POT1 PTEN SDCBP SH3BP5 TCL1A TERF1 TNIK TNKS1BP1 TNKS2 UBASH3B USP25 VPS33A	307 interacting genes: - ABI2 ANKRD33 ANKRD36B ANKRD40 ANP32B APIP ARFIP2 ARL6IP1 BCL2L15 BEND7 C11orf68 C1orf109 C1orf35 C2CD2L CABP5 CADM1 CADPS CALCOCO2 CALM1 CALM2 CALM3 CAV2 CBR3 CBY2 CCDC102B CCDC106 CD6 CD63 CDA CDC34 CDCP1 CDIPT CDKN2D CEP55 CEP85 CGGBP1 CHIC2 CHMP1A CLK2 CLK3 CMTM5 COX4I1 CRX CRYAA CT45A1 CT45A10 CT45A3 CT45A5 CTBP2 CTDSP1 CUTC CYHR1 DCTD DCTPP1 DDX39B DERL3 DMC1 DNM2 DRAP1 DTNBP1 DYNLT1 EAF1 EDARADD EFNB1 EFNB2 EIF1AD EIF5A EIF5A2 ELAVL1 EMILIN3 ENOX1 ENTR1 EPHB2 ERICH2 EXOSC4 FADD FAM118A FAM118B FAM9A FAM9B FHL3 FHL5 FLAD1 FOXP2 FTH1 FTL GET4 GGPS1 GKAP1 GNMT GOLT1B GPATCH11 GPR37 GRIA1 GRIA2 GRIA3 GRIA4 GRIK1 GRIK2 GRM2 GRM3 GRM7 GRXCR1 GSC2 GSG1 HEXIM2 HHAT HIVEP1 HMBOX1 HMGB3 HNRNPC HOMER3 HOMEZ HOXA1 HOXA7 HPRT1 HSBP1 HSF2BP HUS1 ID3 IGFBP6 IHO1 IKZF1 IL5RA INO80E KATNBL1 KCNH1 KCNJ2 KCTD1 KCTD6 KCTD9 KHDRBS2 KLHL12 KLHL2 KRT14 KRTAP1-3 KRTAP1-5 KRTAP10-3 KRTAP10-7 KRTAP5-9 LDB2 LDHB LDOC1 LEPROTL1 LGALS2 LSM6 LURAP1L LZTFL1 MAD2L1 MAPK9 MAPRE3 MATN4 MBD3 MED4 MEOX1 MEOX2 MGLL MID2 MINDY3 MKRN1 MOBP MRFAP1 MRFAP1L1 MTUS2 MYBPC2 MYLIP N4BP3 NADK NAGK NAPB NECAB2 NF2 NFASC NKAPD1 NOTCH2NLA NT5C2 OCM ODAM OPTN OSTF1 PCBD1 PCYT1A PDCD6IP PDE4DIP PDE9A PDLIM4 PDZK1IP1 PFDN5 PHC2 PHF11 PIH1D2 PNMA1 PNMA2 POLR2J POLR3K PPARA PRPF38A PRPF40A PRR13 PSMB3 PSMC6 PSME2 PSTPIP1 PTEN PTPRJ PTS PUF60 PYCR3 RAB5A RALY RBM39 REEP6 REL RIC8A RNF11 RNH1 ROPN1 RP9 RP9P RPIA RPL22 RPRD1A RPRM RPS26 RRM2 RRS1 RTL8B RTN1 RUNDC3A S100B SCG3 SCML1 SDC1 SDC2 SDC4 SDCBP2 SEPTIN1 SEPTIN3 SET SFT2D1 SIAH1 SLC50A1 SLC6A5 SMARCA2 SNRPA SNX1 SOX4 SPANXN3 SREK1IP1 SRSF11 SRSF3 SRSF7 SSC5D SSNA1 STX1A SUB1 SULT1B1 SYNGR1 SYPL1 SYS1 TCF21 TCF4 TDO2 TEKT1 TFCP2 TGFA THG1L TIFA TKFC TLE5 TMCO2 TMEM17 TMEM239 TNFAIP8 TNFAIP8L3 TNKS TRAF5 TRARG1 TRIM27 TRIM32 TRIM38 TRIM54 TRIP13 TSN UBB UBC UBE2A UBE2K UBE2R2 ULK1 WASHC1 WASHC3 WASL WDR91 YIF1A ZBTB14 ZBTB8A ZCCHC10 ZCCHC17 ZMYND12 ZNF343 ZNF485 ZNF660 ZNF768 ZRANB1 ZSCAN23
Entrez ID		8658	6386
HPRD ID		04490	03741
Ensembl ID		ENSG00000173273	ENSG00000137575
Uniprot IDs		O95271	A0A024R7Z5 B4DHN5 G5EA09 O00560
PDB IDs		2RF5 3UDD 3UH2 3UH4 4DVI 4I9I 4K4E 4K4F 4KRS 4LI6 4LI7 4LI8 4MSG 4MSK 4MT9 4N3R 4N4V 4OA7 4TOR 4TOS 4U6A 4UUH 4UW1 4W5S 4W6E 5EBT 5ECE 5ETY 5GP7 5JHQ 5JTI 5JU5 5KNI 6QXU 6URQ	1N99 1NTE 1OBX 1OBY 1OBZ 1R6J 1V1T 1W9E 1W9O 1W9Q 1YBO 4Z33 6R9H 6RLC
Enriched GO Terms of Interacting Partners?
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