ACTL6A and TRRAP

Number of citations of the paper that reports this interaction (PubMedID 22939629)
326

Data Source:
BioGRID (affinity chromatography technology, biochemical, affinity chromatography technology, biochemical)
HPRD (in vivo)

		ACTL6A	TRRAP
Description		actin like 6A	transformation/transcription domain associated protein
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Plasma Membrane SWI/SNF Complex Ino80 Complex Protein-containing Complex NuA4 Histone Acetyltransferase Complex NpBAF Complex	SAGA Complex Swr1 Complex Nucleus Nucleoplasm Golgi Apparatus Transcription Factor TFTC Complex NuA4 Histone Acetyltransferase Complex
	Molecular Function	Chromatin Binding Transcription Coactivator Activity Protein Binding Nucleosomal DNA Binding	Transcription Coregulator Activity Protein Binding Kinase Activity
	Biological Process	Blastocyst Formation Neural Retina Development DNA Repair DNA Recombination Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Signal Transduction Nervous System Development Spinal Cord Development Regulation Of Growth Histone H4 Acetylation Histone H2A Acetylation Positive Regulation Of Transcription, DNA-templated	DNA Repair Regulation Of Transcription, DNA-templated Histone Acetylation Histone Deubiquitination Histone H4 Acetylation Histone H2A Acetylation
Pathways		HATs acetylate histones RMTs methylate histone arginines UCH proteinases DNA Damage Recognition in GG-NER RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex HATs acetylate histones Ub-specific processing proteases
Drugs
Diseases
GWAS		Pars opercularis volume ( 31530798)	Hemoglobin levels ( 32327693) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		16 interacting genes: ARHGDIA CDK2 CDK9 ERO1B EWSR1 FLII MRGBP MYC OGT POLR2A PTEN RELA RUVBL1 SMARCA2 SMARCA4 TRRAP	19 interacting genes: ACTL6A ATXN7 AURKA BRCA1 BRD8 CDC42 CTNNB1 E2F1 E2F4 EP400 ESR1 KAT2A MAX MMS22L MRGBP MYC PYGO2 SKP1 TCF3
Entrez ID		86	8295
HPRD ID		05389	04310
Ensembl ID		ENSG00000136518	ENSG00000196367
Uniprot IDs		O96019	Q9Y4A5
PDB IDs		6LTJ
Enriched GO Terms of Interacting Partners?
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