ACTL6A and RUVBL1

Number of citations of the paper that reports this interaction (PubMedID 11839798)
61

Data Source:
HPRD (in vivo)

		ACTL6A	RUVBL1
Description		actin like 6A	RuvB like AAA ATPase 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Plasma Membrane SWI/SNF Complex Ino80 Complex Protein-containing Complex NuA4 Histone Acetyltransferase Complex NpBAF Complex	Swr1 Complex Nucleus Nucleoplasm Microtubule Organizing Center Cytosol Membrane Nuclear Matrix Ino80 Complex NuA4 Histone Acetyltransferase Complex Extracellular Exosome MLL1 Complex R2TP Complex Dynein Axonemal Particle Ribonucleoprotein Complex
	Molecular Function	Chromatin Binding Transcription Coactivator Activity Protein Binding Nucleosomal DNA Binding	TFIID-class Transcription Factor Complex Binding DNA Helicase Activity Transcription Coactivator Activity Protein Binding ATP Binding ATP Hydrolysis Activity TBP-class Protein Binding 5'-3' DNA Helicase Activity ADP Binding Cadherin Binding ATPase Binding
	Biological Process	Blastocyst Formation Neural Retina Development DNA Repair DNA Recombination Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Signal Transduction Nervous System Development Spinal Cord Development Regulation Of Growth Histone H4 Acetylation Histone H2A Acetylation Positive Regulation Of Transcription, DNA-templated	Box C/D SnoRNP Assembly DNA Repair DNA Recombination Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Cell Cycle Spermatogenesis Histone Acetylation DNA Duplex Unwinding Regulation Of Growth Histone H4 Acetylation Histone H2A Acetylation Positive Regulation Of Transcription, DNA-templated Cell Division Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Telomerase RNA Localization To Cajal Body
Pathways		HATs acetylate histones RMTs methylate histone arginines UCH proteinases DNA Damage Recognition in GG-NER RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	Telomere Extension By Telomerase Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex HATs acetylate histones UCH proteinases Ub-specific processing proteases DNA Damage Recognition in GG-NER Deposition of new CENPA-containing nucleosomes at the centromere
Drugs
Diseases
GWAS		Pars opercularis volume ( 31530798)	Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Gestational age at birth (maternal effect) ( 28877031) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		16 interacting genes: ARHGDIA CDK2 CDK9 ERO1B EWSR1 FLII MRGBP MYC OGT POLR2A PTEN RELA RUVBL1 SMARCA2 SMARCA4 TRRAP	21 interacting genes: ACTL6A CEP126 CTNNB1 DKC1 FBL LZTR1 MRGBP MYC NEDD4 OFD1 OGT PLG RUVBL2 STOM SUMO2 TAF9 TBP TERT TK1 YY1 ZNHIT2
Entrez ID		86	8607
HPRD ID		05389	09143
Ensembl ID		ENSG00000136518	ENSG00000175792
Uniprot IDs		O96019	A0A384MTR5 B3KRS7 E7ETR0 Q9Y265
PDB IDs		6LTJ	2C9O 2XSZ 5OAF 6FO1 6HTS 6IGM 6K0R 6QI8 6QI9 7AHO
Enriched GO Terms of Interacting Partners?
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