TRRAP and ACTL6A

Number of citations of the paper that reports this interaction (PubMedID 22939629)
326

Data Source:
BioGRID (affinity chromatography technology, biochemical, affinity chromatography technology, biochemical)
HPRD (in vivo)

		TRRAP	ACTL6A
Description		transformation/transcription domain associated protein	actin like 6A
Image		No pdb structure
GO Annotations	Cellular Component	SAGA Complex Swr1 Complex Nucleus Nucleoplasm Golgi Apparatus Transcription Factor TFTC Complex NuA4 Histone Acetyltransferase Complex	Chromatin Nucleus Nucleoplasm Plasma Membrane SWI/SNF Complex Ino80 Complex Protein-containing Complex NuA4 Histone Acetyltransferase Complex NpBAF Complex
	Molecular Function	Transcription Coregulator Activity Protein Binding Kinase Activity	Chromatin Binding Transcription Coactivator Activity Protein Binding Nucleosomal DNA Binding
	Biological Process	DNA Repair Regulation Of Transcription, DNA-templated Histone Acetylation Histone Deubiquitination Histone H4 Acetylation Histone H2A Acetylation	Blastocyst Formation Neural Retina Development DNA Repair DNA Recombination Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Signal Transduction Nervous System Development Spinal Cord Development Regulation Of Growth Histone H4 Acetylation Histone H2A Acetylation Positive Regulation Of Transcription, DNA-templated
Pathways		Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex HATs acetylate histones Ub-specific processing proteases	HATs acetylate histones RMTs methylate histone arginines UCH proteinases DNA Damage Recognition in GG-NER RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Drugs
Diseases
GWAS		Hemoglobin levels ( 32327693) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)	Pars opercularis volume ( 31530798)
Interacting Genes		19 interacting genes: ACTL6A ATXN7 AURKA BRCA1 BRD8 CDC42 CTNNB1 E2F1 E2F4 EP400 ESR1 KAT2A MAX MMS22L MRGBP MYC PYGO2 SKP1 TCF3	16 interacting genes: ARHGDIA CDK2 CDK9 ERO1B EWSR1 FLII MRGBP MYC OGT POLR2A PTEN RELA RUVBL1 SMARCA2 SMARCA4 TRRAP
Entrez ID		8295	86
HPRD ID		04310	05389
Ensembl ID		ENSG00000196367	ENSG00000136518
Uniprot IDs		Q9Y4A5	O96019
PDB IDs			6LTJ
Enriched GO Terms of Interacting Partners?
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