EAF1 and KEAP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		EAF1	KEAP1
Description		ELL associated factor 1	kelch like ECH associated protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Transcription Elongation Factor Complex Cajal Body Nuclear Body Nuclear Speck Super Elongation Complex Intracellular Membrane-bounded Organelle Intercellular Bridge	Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Actin Filament Inclusion Body Midbody Cul3-RING Ubiquitin Ligase Complex Centriolar Satellite
	Molecular Function	Transcription Elongation Regulator Activity Protein Binding	Protein Binding Transcription Factor Binding Identical Protein Binding Disordered Domain Specific Binding
	Biological Process	Regulation Of Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated	In Utero Embryonic Development Ubiquitin-dependent Protein Catabolic Process Regulation Of Autophagy Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Oxidative Stress Cytoplasmic Sequestering Of Transcription Factor Negative Regulation Of DNA-binding Transcription Factor Activity Regulation Of Epidermal Cell Differentiation Cellular Response To Interleukin-4
Pathways		Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation	Ub-specific processing proteases ROS sensing by NFE2L2 ROS sensing by NFE2L2 Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs			Dimethyl fumarate
Diseases
GWAS			Body mass index and diastolic blood pressure (bivariate analysis) ( 33539483) Body mass index and systolic blood pressure (bivariate analysis) ( 33539483) Body mass index and waist-hip ratio (pleiotropy) ( 29868124) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)
Interacting Genes		53 interacting genes: AP2M1 APP ARID4B BEND7 BHLHB9 CCDC150 CCDC33 CEP70 CEP76 DNTTIP1 DPPA4 ELL ELL2 ELL3 FAM228A GADD45GIP1 GAS8 GCSAML GOLGA6L9 GRHL3 GTF2H1 GTF2H4 HOMER3 HSF2BP KEAP1 KIAA1328 MAB21L3 MIPOL1 NUMB PAX6 PICK1 PIH1D1 PSME3 RYBP SDCBP SEMG1 SH3RF1 SRP14 STAC3 TCEA2 TFCP2 TFPT TLE5 TNFAIP8 TNNI1 TRAF2 TRIM62 VAX1 YAF2 ZBTB14 ZNF143 ZNF202 ZNF620	96 interacting genes: ADH5 AK4 AMER1 ANKS1A ARPC1B ASTN1 ATG5 BAD BNIP3L BPTF C2orf68 CARD10 CARM1 CAT CCNB1IP1 CDH1 CDK6 CLU COL1A1 COL2A1 CPEB2 CSNK2A1 CTTN DPP3 EAF1 EGFR ERBIN ERICH5 ETF1 FAM117B FBXL17 GLRX5 GPR151 GYPA HSP90AA1 HSP90AB1 ICAM1 IFIH1 IPO11 IQCC IRF1 KLHL12 KLHL2 KLHL3 KPNA6 LAMC1 LAMTOR5 LONP1 LSM3 MAD2L1 MAPKBP1 MCM3 MCMBP MYO7A NFE2L2 NIBAN2 NTAQ1 NUDT4 NUP50 OXR1 PALB2 PANX1 PAQR4 PDCD6IP PPP1R13L PRKAG1 PTMA RAF1 RECK RELA RTN4R S1PR2 SDC1 SENP1 SLC5A5 SMARCD1 SNRPN SQSTM1 STAP2 STK3 STK4 TBC1D7 TENT5A TERF1 TET2 TRIM15 UBC UBE2D1 USP15 VAC14 WDR83 WHRN ZNF121 ZNF177 ZNF266 ZSCAN32
Entrez ID		85403	9817
HPRD ID		12209	12079
Ensembl ID		ENSG00000144597	ENSG00000079999
Uniprot IDs		Q96JC9	A0A024R7C0 Q14145
PDB IDs			1U6D 1ZGK 2FLU 3VNG 3VNH 3ZGC 3ZGD 4CXI 4CXJ 4CXT 4IFJ 4IFL 4IFN 4IN4 4IQK 4L7B 4L7C 4L7D 4N1B 4XMB 5DAD 5DAF 5F72 5GIT 5NLB 5WFL 5WFV 5WG1 5WHL 5WHO 5WIY 5X54 6FFM 6FMP 6FMQ 6HWS 6LRZ 6ROG 6SP1 6SP4 6T7V 6T7Z 6TG8 6TYM 6TYP 6UF0 6V6Z 6W66 6W67 6W68 6W69 6WCQ 6Z6A
Enriched GO Terms of Interacting Partners?
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