KEAP1 and CPEB2

Number of citations of the paper that reports this interaction (PubMedID 22157746)
35

Data Source:
BioGRID (two hybrid)

		KEAP1	CPEB2
Description		kelch like ECH associated protein 1	cytoplasmic polyadenylation element binding protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Actin Filament Inclusion Body Midbody Cul3-RING Ubiquitin Ligase Complex Centriolar Satellite	Nucleus Cytoplasm Neuron Projection Synapse Messenger Ribonucleoprotein Complex
	Molecular Function	Protein Binding Transcription Factor Binding Identical Protein Binding Disordered Domain Specific Binding	Translation Repressor Activity, MRNA Regulatory Element Binding RNA Binding MRNA 3'-UTR Binding GTPase Inhibitor Activity Translation Factor Activity, RNA Binding MRNA 3'-UTR AU-rich Region Binding Ribosome Binding Ribosomal Large Subunit Binding Ribosomal Small Subunit Binding
	Biological Process	In Utero Embryonic Development Ubiquitin-dependent Protein Catabolic Process Regulation Of Autophagy Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Oxidative Stress Cytoplasmic Sequestering Of Transcription Factor Negative Regulation Of DNA-binding Transcription Factor Activity Regulation Of Epidermal Cell Differentiation Cellular Response To Interleukin-4	Translation Cellular Response To Insulin Stimulus Negative Regulation Of GTPase Activity Cellular Response To Oxidative Stress Cellular Response To Arsenic-containing Substance Cellular Response To Hypoxia Negative Regulation Of Cytoplasmic Translational Elongation Negative Regulation Of Cytoplasmic Translation
Pathways		Ub-specific processing proteases ROS sensing by NFE2L2 ROS sensing by NFE2L2 Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Dimethyl fumarate
Diseases
GWAS		Body mass index and diastolic blood pressure (bivariate analysis) ( 33539483) Body mass index and systolic blood pressure (bivariate analysis) ( 33539483) Body mass index and waist-hip ratio (pleiotropy) ( 29868124) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)	Cognitive flexibility ( 30134085) Triglyceride levels ( 32203549) Type 2 diabetes ( 33479058)
Interacting Genes		96 interacting genes: ADH5 AK4 AMER1 ANKS1A ARPC1B ASTN1 ATG5 BAD BNIP3L BPTF C2orf68 CARD10 CARM1 CAT CCNB1IP1 CDH1 CDK6 CLU COL1A1 COL2A1 CPEB2 CSNK2A1 CTTN DPP3 EAF1 EGFR ERBIN ERICH5 ETF1 FAM117B FBXL17 GLRX5 GPR151 GYPA HSP90AA1 HSP90AB1 ICAM1 IFIH1 IPO11 IQCC IRF1 KLHL12 KLHL2 KLHL3 KPNA6 LAMC1 LAMTOR5 LONP1 LSM3 MAD2L1 MAPKBP1 MCM3 MCMBP MYO7A NFE2L2 NIBAN2 NTAQ1 NUDT4 NUP50 OXR1 PALB2 PANX1 PAQR4 PDCD6IP PPP1R13L PRKAG1 PTMA RAF1 RECK RELA RTN4R S1PR2 SDC1 SENP1 SLC5A5 SMARCD1 SNRPN SQSTM1 STAP2 STK3 STK4 TBC1D7 TENT5A TERF1 TET2 TRIM15 UBC UBE2D1 USP15 VAC14 WDR83 WHRN ZNF121 ZNF177 ZNF266 ZSCAN32	22 interacting genes: ATG2A ATP1B2 BSCL2 C2CD2L CAPN15 CC2D2A COPS7A ERI3 GAA GABBR1 GPX7 KEAP1 MT-ATP6 NECAB2 OTUB1 PIGS PSAP PUF60 SEMA4B SORBS3 SPARC TUBA1A
Entrez ID		9817	132864
HPRD ID		12079	16744
Ensembl ID		ENSG00000079999	ENSG00000137449
Uniprot IDs		A0A024R7C0 Q14145	A0A5K1VW61 A0A5K1VW71 A0A5K1VW79 A0A5K1VW93 Q7Z5Q1
PDB IDs		1U6D 1ZGK 2FLU 3VNG 3VNH 3ZGC 3ZGD 4CXI 4CXJ 4CXT 4IFJ 4IFL 4IFN 4IN4 4IQK 4L7B 4L7C 4L7D 4N1B 4XMB 5DAD 5DAF 5F72 5GIT 5NLB 5WFL 5WFV 5WG1 5WHL 5WHO 5WIY 5X54 6FFM 6FMP 6FMQ 6HWS 6LRZ 6ROG 6SP1 6SP4 6T7V 6T7Z 6TG8 6TYM 6TYP 6UF0 6V6Z 6W66 6W67 6W68 6W69 6WCQ 6Z6A
Enriched GO Terms of Interacting Partners?
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