GAS7 and CYFIP1

Number of citations of the paper that reports this interaction (PubMedID 16055720)
92

Data Source:
BioGRID (pull down)

		GAS7	CYFIP1
Description		growth arrest specific 7	cytoplasmic FMR1 interacting protein 1
Image
GO Annotations	Cellular Component	Cytoplasm Actin Filament Plasma Membrane	Ruffle Extracellular Region Cytosol MRNA Cap Binding Complex Focal Adhesion Lamellipodium SCAR Complex Filopodium Tip Secretory Granule Lumen Specific Granule Lumen Neuron Projection Neuronal Cell Body Terminal Bouton Dendritic Spine Dendritic Growth Cone Axonal Growth Cone Synapse Perinuclear Region Of Cytoplasm Excitatory Synapse Extracellular Exosome Central Region Of Growth Cone Peripheral Region Of Growth Cone Tertiary Granule Lumen
	Molecular Function	Protein Binding Actin Filament Binding	RNA 7-methylguanosine Cap Binding Protein Binding Small GTPase Binding Translation Regulator Activity Actin Filament Binding
	Biological Process	Actin Filament Polymerization Neuron Projection Morphogenesis	Cell Morphogenesis Regulation Of Translation Axon Guidance Regulation Of Cell Shape Positive Regulation Of Lamellipodium Assembly Rac Protein Signal Transduction Cell Projection Assembly Lamellipodium Assembly Ruffle Organization Regulation Of Myelination Cellular Response To Insulin Stimulus Positive Regulation Of Axon Extension Axon Extension Cognition Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Response To Electrical Stimulus Dendrite Extension Modification Of Synaptic Structure Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Positive Regulation Of Dendrite Development Positive Regulation Of Ruffle Assembly Negative Regulation Of Synaptic Vesicle Recycling Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways			Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Neutrophil degranulation RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Declining hemoglobin trajectory in blood donors ( 33491795) Glaucoma ( 30104761 31959993 30054594) Glaucoma (high intraocular pressure) ( 33627673) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 33627673 29891935) Gut microbiota relative abundance (Prevotella) ( 33208821) Heel bone mineral density ( 30598549) Intraocular pressure ( 29617998 25173106 24002674 22570627 31798171 29785010 31959993 30054594 28073927 29235454) Medication use (antiglaucoma preparations and miotics) ( 31015401) Proteinuria and chronic kidney disease ( 26420894)	Bipolar disorder ( 34099189) Heel bone mineral density ( 30598549) Platelet distribution width ( 32888494) Triglyceride levels x loop diuretics use interaction ( 31806883) World class endurance athleticism ( 32612638)
Interacting Genes		26 interacting genes: ABI1 ACTA1 APBB1IP ATXN1L CDC37 CREB3L2 CYFIP1 CYFIP2 DIAPH1 FMNL1 GAPDH KHDRBS1 LSM4 MCRS1 MYBPC2 NCKAP1 NCKAP1L NCKIPSD NTAQ1 PACSIN1 RPLP0 SF1 SF3A1 SFPQ WASF2 YIF1A	19 interacting genes: ACTA1 APBB1 EFHC2 EFTUD2 FMR1 FXR2 GAS7 GNB1 MEOX1 MYO16 NUP98 NYAP1 NYAP2 PPP1CC PRPF40A RAC1 RFX6 SCTR TCERG1
Entrez ID		8522	23191
HPRD ID		16011	05890
Ensembl ID		ENSG00000007237	ENSG00000273749
Uniprot IDs		O60861	Q7L576
PDB IDs		2LX7 2YSH	3P8C 4N78
Enriched GO Terms of Interacting Partners?
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