GAS7 and DIAPH1

Number of citations of the paper that reports this interaction (PubMedID 16055720)
92

Data Source:
BioGRID (pull down)

		GAS7	DIAPH1
Description		growth arrest specific 7	diaphanous related formin 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Actin Filament Plasma Membrane	Nucleus Cytoplasm Microtubule Organizing Center Cytosol Plasma Membrane Secretory Granule Membrane Ruffle Membrane Mitotic Spindle Ficolin-1-rich Granule Membrane
	Molecular Function	Protein Binding Actin Filament Binding	RNA Binding Actin Binding Signaling Receptor Binding Protein Binding Small GTPase Binding Transmembrane Transporter Binding
	Biological Process	Actin Filament Polymerization Neuron Projection Morphogenesis	Cytoskeleton Organization Sensory Perception Of Sound Regulation Of Cell Shape Actin Cytoskeleton Organization Actin Filament Polymerization Positive Regulation Of Cell Migration Regulation Of Microtubule-based Process Protein Localization To Microtubule Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cytoskeleton Organization Cellular Response To Histamine
Pathways			RHO GTPases Activate Formins ERBB2 Regulates Cell Motility Neutrophil degranulation RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RHOD GTPase cycle RHOF GTPase cycle
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Declining hemoglobin trajectory in blood donors ( 33491795) Glaucoma ( 30104761 31959993 30054594) Glaucoma (high intraocular pressure) ( 33627673) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 33627673 29891935) Gut microbiota relative abundance (Prevotella) ( 33208821) Heel bone mineral density ( 30598549) Intraocular pressure ( 29617998 25173106 24002674 22570627 31798171 29785010 31959993 30054594 28073927 29235454) Medication use (antiglaucoma preparations and miotics) ( 31015401) Proteinuria and chronic kidney disease ( 26420894)	Age at first birth ( 34211149) Allergic disease (asthma, hay fever or eczema) ( 29083406) Mean platelet volume ( 32888494 27863252) Refractive error ( 32231278) Triglyceride levels ( 32203549)
Interacting Genes		26 interacting genes: ABI1 ACTA1 APBB1IP ATXN1L CDC37 CREB3L2 CYFIP1 CYFIP2 DIAPH1 FMNL1 GAPDH KHDRBS1 LSM4 MCRS1 MYBPC2 NCKAP1 NCKAP1L NCKIPSD NTAQ1 PACSIN1 RPLP0 SF1 SF3A1 SFPQ WASF2 YIF1A	17 interacting genes: APBB1 BAIAP2 CDC42 CDC7 CENPA GAS7 NEDD4 PAX6 PKD2 PRPF40A PTPRF RAC1 RHOA RHOC TCERG1 WBP4 XPO6
Entrez ID		8522	1729
HPRD ID		16011	03670
Ensembl ID		ENSG00000007237	ENSG00000131504
Uniprot IDs		O60861	A0A2R8Y5N1 O60610 Q6URC4
PDB IDs		2LX7 2YSH
Enriched GO Terms of Interacting Partners?
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