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TMEM60 and CD74
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
86
Data Source:
BioGRID
(two hybrid)
TMEM60
CD74
Description
transmembrane protein 60
CD74 molecule
Image
No pdb structure
GO Annotations
Cellular Component
Integral Component Of Membrane
Golgi Membrane
Nucleus
Cytoplasm
Lysosomal Membrane
Multivesicular Body
Vacuole
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
ER To Golgi Transport Vesicle Membrane
Membrane
Integral Component Of Membrane
Transport Vesicle Membrane
Endocytic Vesicle Membrane
Clathrin-coated Endocytic Vesicle Membrane
Trans-Golgi Network Membrane
Protein-containing Complex
Macrophage Migration Inhibitory Factor Receptor Complex
NOS2-CD74 Complex
MHC Class II Protein Complex
Lysosomal Lumen
Extracellular Exosome
Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
Molecular Function
Protein Binding
Amyloid-beta Binding
Cytokine Receptor Activity
Protein Binding
Cytokine Binding
MHC Class II Protein Complex Binding
Macrophage Migration Inhibitory Factor Binding
MHC Class II Protein Binding
CD4 Receptor Binding
MHC Class II Protein Binding, Via Antigen Binding Groove
Identical Protein Binding
Protein Folding Chaperone
Nitric-oxide Synthase Binding
Biological Process
Prostaglandin Biosynthetic Process
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Cytokine-mediated Signaling Pathway
T Cell Activation Involved In Immune Response
Positive Regulation Of Dendritic Cell Antigen Processing And Presentation
Negative Regulation Of Peptide Secretion
Positive Regulation Of Type 2 Immune Response
Negative Regulation Of Mature B Cell Apoptotic Process
Intracellular Protein Transport
Cell Population Proliferation
Positive Regulation Of Gene Expression
Immunoglobulin Mediated Immune Response
Antigen Processing And Presentation
Antigen Processing And Presentation Of Endogenous Antigen
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Negative Regulation Of Cell Migration
Positive Regulation Of B Cell Proliferation
Positive Regulation Of Prostaglandin Biosynthetic Process
Positive Regulation Of Chemokine Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Kinase Activity
Response To Interferon-gamma
Macrophage Migration Inhibitory Factor Signaling Pathway
Regulation Of Macrophage Activation
Negative Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of MAPK Cascade
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
T Cell Selection
Positive Thymic T Cell Selection
Negative Thymic T Cell Selection
Negative Regulation Of T Cell Differentiation
Positive Regulation Of T Cell Differentiation
Positive Regulation Of Monocyte Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Viral Entry Into Host Cell
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Chaperone Cofactor-dependent Protein Refolding
Positive Regulation Of Macrophage Cytokine Production
Protein-containing Complex Assembly
Protein Trimerization
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Neutrophil Chemotaxis
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway
Pathways
Cell surface interactions at the vascular wall
MHC class II antigen presentation
Drugs
Diseases
GWAS
Chronic kidney disease (
20383146
)
Estimated glomerular filtration rate (
31152163
31451708
30604766
)
Estimated glomerular filtration rate in non-diabetics (
31451708
)
Glomerular filtration rate (creatinine) (
28452372
26831199
)
Glomerular filtration rate in non diabetics (creatinine) (
26831199
)
Crohn's disease (
28067908
)
Inflammatory bowel disease (
28067908
)
Post bronchodilator FEV1/FVC ratio (
26634245
)
Interacting Genes
89 interacting genes:
AMIGO1
ANKS6
APOL2
AQP2
AQP6
ASGR2
BEST2
BIK
BSND
CD300A
CD53
CD74
CLDN7
CNR2
CPLX4
CYB5R3
EBP
EDA
ERGIC3
EVI2B
FAM209A
FFAR2
FNDC9
GJA8
GJB5
GJB6
GORAB
GPR152
GPR42
GPX8
HERPUD2
HIBADH
HSD17B13
IFNGR2
KCNK5
KIAA2013
LEUTX
LHFPL5
LMNA
LRRC3B
LRRC59
MFF
MGST3
MMD
MMGT1
PAGE1
PGRMC2
PI16
REEP2
REEP4
RETREG3
RHCG
RNASEK
SCN3B
SLC10A1
SLC10A6
SLC13A4
SLC16A2
SLC18A1
SLC23A2
SLC30A2
SLC30A4
SLC35E3
SLC38A1
SLC39A2
SLC4A1
SLC7A8
SPAG4
SPNS3
SSMEM1
STOM
STX1A
SYT1
THAP4
TLCD4
TMCO5A
TMED9
TMEM139
TMEM14B
TMEM203
TMEM237
TMEM45B
TMEM52B
TMEM86B
TMEM9
TMPPE
TMPRSS2
TTYH1
VMA21
44 interacting genes:
APP
BET1
C14orf180
CCR1
CD1D
CD44
CLDN19
CLEC7A
CMTM7
CTSF
CTSL
EDDM3B
ERG28
FDFT1
FXYD6
HADHA
HLA-DMA
HLA-DMB
HLA-DPA1
HLA-DPB1
HLA-DQA1
HLA-DQB1
HLA-DRA
LAMTOR5
LPAR3
MAP3K1
MIF
PGA4
PLP1
PLPP4
POMGNT1
PTCH1
RTP2
SEC22A
SERP1
SLC35B1
SMIM1
TEX11
TMEM120B
TMEM243
TMEM254
TMEM60
TMEM97
UPK2
Entrez ID
85025
972
HPRD ID
12923
00825
Ensembl ID
ENSG00000135211
ENSG00000019582
Uniprot IDs
Q9H2L4
P04233
PDB IDs
1A6A
1ICF
1IIE
1L3H
1MUJ
3PDO
3PGC
3PGD
3QXA
3QXD
4AEN
4AH2
4X5W
5KSU
5KSV
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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