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CD74 and CD1D
Number of citations of the paper that reports this interaction (PubMedID
11754812
)
73
Data Source:
HPRD
(in vivo)
CD74
CD1D
Description
CD74 molecule
CD1d molecule
Image
GO Annotations
Cellular Component
Golgi Membrane
Nucleus
Cytoplasm
Lysosomal Membrane
Multivesicular Body
Vacuole
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
ER To Golgi Transport Vesicle Membrane
Membrane
Integral Component Of Membrane
Transport Vesicle Membrane
Endocytic Vesicle Membrane
Clathrin-coated Endocytic Vesicle Membrane
Trans-Golgi Network Membrane
Protein-containing Complex
Macrophage Migration Inhibitory Factor Receptor Complex
NOS2-CD74 Complex
MHC Class II Protein Complex
Lysosomal Lumen
Extracellular Exosome
Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
Extracellular Space
Cytoplasm
Lysosome
Lysosomal Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Plasma Membrane
Integral Component Of Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Endosome Membrane
Basolateral Plasma Membrane
Molecular Function
Amyloid-beta Binding
Cytokine Receptor Activity
Protein Binding
Cytokine Binding
MHC Class II Protein Complex Binding
Macrophage Migration Inhibitory Factor Binding
MHC Class II Protein Binding
CD4 Receptor Binding
MHC Class II Protein Binding, Via Antigen Binding Groove
Identical Protein Binding
Protein Folding Chaperone
Nitric-oxide Synthase Binding
Protein Binding
Beta-2-microglobulin Binding
Lipid Antigen Binding
Endogenous Lipid Antigen Binding
Exogenous Lipid Antigen Binding
Histone Binding
Cell Adhesion Molecule Binding
Lipopeptide Binding
Biological Process
Prostaglandin Biosynthetic Process
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Cytokine-mediated Signaling Pathway
T Cell Activation Involved In Immune Response
Positive Regulation Of Dendritic Cell Antigen Processing And Presentation
Negative Regulation Of Peptide Secretion
Positive Regulation Of Type 2 Immune Response
Negative Regulation Of Mature B Cell Apoptotic Process
Intracellular Protein Transport
Cell Population Proliferation
Positive Regulation Of Gene Expression
Immunoglobulin Mediated Immune Response
Antigen Processing And Presentation
Antigen Processing And Presentation Of Endogenous Antigen
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Negative Regulation Of Cell Migration
Positive Regulation Of B Cell Proliferation
Positive Regulation Of Prostaglandin Biosynthetic Process
Positive Regulation Of Chemokine Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Kinase Activity
Response To Interferon-gamma
Macrophage Migration Inhibitory Factor Signaling Pathway
Regulation Of Macrophage Activation
Negative Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of MAPK Cascade
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
T Cell Selection
Positive Thymic T Cell Selection
Negative Thymic T Cell Selection
Negative Regulation Of T Cell Differentiation
Positive Regulation Of T Cell Differentiation
Positive Regulation Of Monocyte Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Viral Entry Into Host Cell
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Chaperone Cofactor-dependent Protein Refolding
Positive Regulation Of Macrophage Cytokine Production
Protein-containing Complex Assembly
Protein Trimerization
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Neutrophil Chemotaxis
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway
Positive Regulation Of T Cell Mediated Cytotoxicity
Immune Response
Detection Of Bacterium
Heterotypic Cell-cell Adhesion
Positive Regulation Of T Cell Proliferation
T Cell Selection
Innate Immune Response
Positive Regulation Of Innate Immune Response
Antigen Processing And Presentation, Endogenous Lipid Antigen Via MHC Class Ib
Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib
Pathways
Cell surface interactions at the vascular wall
MHC class II antigen presentation
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
cis-tetracosenoyl sulfatide
Diseases
GWAS
Crohn's disease (
28067908
)
Inflammatory bowel disease (
28067908
)
Post bronchodilator FEV1/FVC ratio (
26634245
)
Dental caries (decayed and filled deciduous teeth) (
31533690
)
Interacting Genes
44 interacting genes:
APP
BET1
C14orf180
CCR1
CD1D
CD44
CLDN19
CLEC7A
CMTM7
CTSF
CTSL
EDDM3B
ERG28
FDFT1
FXYD6
HADHA
HLA-DMA
HLA-DMB
HLA-DPA1
HLA-DPB1
HLA-DQA1
HLA-DQB1
HLA-DRA
LAMTOR5
LPAR3
MAP3K1
MIF
PGA4
PLP1
PLPP4
POMGNT1
PTCH1
RTP2
SEC22A
SERP1
SLC35B1
SMIM1
TEX11
TMEM120B
TMEM243
TMEM254
TMEM60
TMEM97
UPK2
8 interacting genes:
APOE
B2M
CALR
CANX
CD74
P4HB
PTPRC
TRB
Entrez ID
972
912
HPRD ID
00825
01780
Ensembl ID
ENSG00000019582
ENSG00000158473
Uniprot IDs
P04233
A0A669KAZ2
A0A669KB34
P15813
PDB IDs
1A6A
1ICF
1IIE
1L3H
1MUJ
3PDO
3PGC
3PGD
3QXA
3QXD
4AEN
4AH2
4X5W
5KSU
5KSV
1ZT4
2PO6
3HUJ
3SDX
3TZV
3U0P
3VWJ
3VWK
4EN3
4LHU
4MNG
4MQ7
4WO4
4WW2
4WWK
6V7Y
6V7Z
6V80
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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