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CD74 and SEC22A
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
86
Data Source:
BioGRID
(two hybrid)
CD74
SEC22A
Description
CD74 molecule
SEC22 homolog A, vesicle trafficking protein
Image
No pdb structure
GO Annotations
Cellular Component
Golgi Membrane
Nucleus
Cytoplasm
Lysosomal Membrane
Multivesicular Body
Vacuole
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
ER To Golgi Transport Vesicle Membrane
Membrane
Integral Component Of Membrane
Transport Vesicle Membrane
Endocytic Vesicle Membrane
Clathrin-coated Endocytic Vesicle Membrane
Trans-Golgi Network Membrane
Protein-containing Complex
Macrophage Migration Inhibitory Factor Receptor Complex
NOS2-CD74 Complex
MHC Class II Protein Complex
Lysosomal Lumen
Extracellular Exosome
Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
Endoplasmic Reticulum Membrane
Integral Component Of Membrane
Molecular Function
Amyloid-beta Binding
Cytokine Receptor Activity
Protein Binding
Cytokine Binding
MHC Class II Protein Complex Binding
Macrophage Migration Inhibitory Factor Binding
MHC Class II Protein Binding
CD4 Receptor Binding
MHC Class II Protein Binding, Via Antigen Binding Groove
Identical Protein Binding
Protein Folding Chaperone
Nitric-oxide Synthase Binding
Transporter Activity
Protein Binding
Biological Process
Prostaglandin Biosynthetic Process
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Cytokine-mediated Signaling Pathway
T Cell Activation Involved In Immune Response
Positive Regulation Of Dendritic Cell Antigen Processing And Presentation
Negative Regulation Of Peptide Secretion
Positive Regulation Of Type 2 Immune Response
Negative Regulation Of Mature B Cell Apoptotic Process
Intracellular Protein Transport
Cell Population Proliferation
Positive Regulation Of Gene Expression
Immunoglobulin Mediated Immune Response
Antigen Processing And Presentation
Antigen Processing And Presentation Of Endogenous Antigen
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Negative Regulation Of Cell Migration
Positive Regulation Of B Cell Proliferation
Positive Regulation Of Prostaglandin Biosynthetic Process
Positive Regulation Of Chemokine Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Kinase Activity
Response To Interferon-gamma
Macrophage Migration Inhibitory Factor Signaling Pathway
Regulation Of Macrophage Activation
Negative Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of MAPK Cascade
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
T Cell Selection
Positive Thymic T Cell Selection
Negative Thymic T Cell Selection
Negative Regulation Of T Cell Differentiation
Positive Regulation Of T Cell Differentiation
Positive Regulation Of Monocyte Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Viral Entry Into Host Cell
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Chaperone Cofactor-dependent Protein Refolding
Positive Regulation Of Macrophage Cytokine Production
Protein-containing Complex Assembly
Protein Trimerization
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Neutrophil Chemotaxis
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Protein Transport
Pathways
Cell surface interactions at the vascular wall
MHC class II antigen presentation
COPII-mediated vesicle transport
Drugs
Diseases
GWAS
Crohn's disease (
28067908
)
Inflammatory bowel disease (
28067908
)
Post bronchodilator FEV1/FVC ratio (
26634245
)
Gestational age at birth (maternal effect) (
28877031
)
Interacting Genes
44 interacting genes:
APP
BET1
C14orf180
CCR1
CD1D
CD44
CLDN19
CLEC7A
CMTM7
CTSF
CTSL
EDDM3B
ERG28
FDFT1
FXYD6
HADHA
HLA-DMA
HLA-DMB
HLA-DPA1
HLA-DPB1
HLA-DQA1
HLA-DQB1
HLA-DRA
LAMTOR5
LPAR3
MAP3K1
MIF
PGA4
PLP1
PLPP4
POMGNT1
PTCH1
RTP2
SEC22A
SERP1
SLC35B1
SMIM1
TEX11
TMEM120B
TMEM243
TMEM254
TMEM60
TMEM97
UPK2
106 interacting genes:
ADGRG3
AQP6
ASGR2
ATP6AP2
BIK
BNIP3
C10orf67
C16orf54
C16orf92
CALN1
CD207
CD300A
CD7
CD74
CISD2
CLEC10A
CLEC12B
CLEC2D
CLEC7A
CREB3L1
CYB561
CYBRD1
DDIT4L
DIABLO
DTX2
EDA
ELOVL4
ERLIN1
ERVFRD-1
FAM174A
FAM209A
FATE1
FUT3
GAD2
GGT6
GJB5
GJB6
GPR37L1
GRAMD2B
HAVCR2
HCST
HSD17B11
ICAM3
KCNJ2
LDAF1
LDLRAD1
LHFPL5
LMNA
LPAR6
LRRC25
LSMEM2
MCOLN1
MFF
MGST2
MINAR1
MS4A14
MS4A3
MS4A4A
MSR1
OPRM1
PACC1
PEX12
PHB
PTGES
RASGRP4
RETREG3
RILPL1
RNASEK
RNF144A
RNF19B
RNF5
SAR1A
SCN3B
SDHAF2
SFTPC
SLC14A2
SLC30A2
SLC35C2
SLC39A2
SMIM3
SPAG4
STMN4
STOML3
STX1A
STX2
STX4
SUSD3
SYNE4
TFR2
TLCD4
TMED9
TMEM106C
TMEM174
TMEM237
TMEM45B
TMEM52B
TMEM71
TMEM79
TMIE
TMPRSS2
TNFSF14
TP53INP1
TRAT1
TRIM59
TYRP1
ZFYVE27
Entrez ID
972
26984
HPRD ID
00825
15313
Ensembl ID
ENSG00000019582
ENSG00000121542
Uniprot IDs
P04233
Q96IW7
PDB IDs
1A6A
1ICF
1IIE
1L3H
1MUJ
3PDO
3PGC
3PGD
3QXA
3QXD
4AEN
4AH2
4X5W
5KSU
5KSV
Enriched GO Terms of Interacting Partners
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