BUD13 and NLRX1

		BUD13	NLRX1
Description		BUD13 homolog	NLR family member X1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm U2-type Spliceosomal Complex RES Complex U2-type Precatalytic Spliceosome	Mitochondrion Mitochondrial Outer Membrane Plasma Membrane Cell Junction
	Molecular Function	RNA Binding Protein Binding	Protein Binding ATP Binding
	Biological Process	MRNA Splicing, Via Spliceosome	Negative Regulation Of Interferon-beta Production Negative Regulation Of Interleukin-6 Production Intracellular Signal Transduction Negative Regulation Of RIG-I Signaling Pathway Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Negative Regulation Of Innate Immune Response Negative Regulation Of Inflammatory Response
Pathways			DDX58/IFIH1-mediated induction of interferon-alpha/beta Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Alcohol consumption (drinks per week) ( 30643258) Apolipoprotein A1 levels ( 32203549) Body mass index ( 31978080) Bone mineral density (femoral neck) in inflammatory bowel disease ( 29603369) Cardiovascular risk factors (age interaction) ( 20838585) Coronary artery disease ( 29263402 29212778) Cutaneous squamous cell carcinoma ( 27424798 32041948) Delirium ( 29631748) Disease progression in age-related macular degeneration ( 29346644) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) General risk tolerance (MTAG) ( 30643258) HDL Cholesterol - Triglycerides (HDLC-TG) ( 21386085) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HIV-1 susceptibility ( 21160409) Hypertriglyceridemia ( 31087446 23505323) LDL cholesterol ( 20864672) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lipid traits ( 24023261) Loneliness ( 27629369) Loneliness (linear analysis) ( 27629369) Low density lipoprotein cholesterol levels ( 33339817) Lung cancer ( 28604730) Manganese levels ( 26025379) Metabolic syndrome ( 30382898 21386085) Metabolic syndrome (bivariate traits) ( 21386085) Metabolite levels ( 23823483 31628463) Platelet count ( 32888494 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245) Pulse pressure ( 30224653) Red cell distribution width ( 28957414) Response to Vitamin E supplementation ( 22437554) Severe influenza A (H1N1) infection ( 26379185) Sum eosinophil basophil counts ( 27863252) Total cholesterol levels ( 33339817) Triglyceride levels ( 32203549 32902719 26763881 30911093 28371326 29615537 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 21909109 18193044 20864672 26160806 24886709) Triglycerides-Blood Pressure (TG-BP) ( 21386085) Vitamin E levels ( 21729881) Waist Circumference - Triglycerides (WC-TG) ( 21386085)	Mean reticulocyte volume ( 32888494)
Interacting Genes		4 interacting genes: GPKOW NLRX1 RBMX2 SRPK2	9 interacting genes: ABCG4 BUD13 C1QTNF5 IFT46 PDZD3 SARM1 SCN3B TMEM25 TMPRSS4
Entrez ID		84811	79671
HPRD ID		11307	17640
Ensembl ID		ENSG00000137656	ENSG00000160703
Uniprot IDs		Q9BRD0	Q86UT6
PDB IDs		5Z56 5Z57 5Z58 6FF4 6FF7 7ABI	3UN9
Enriched GO Terms of Interacting Partners?
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