TRAF7 and UBE2L6

Number of citations of the paper that reports this interaction (PubMedID 19549727)
74

Data Source:
BioGRID (two hybrid)

		TRAF7	UBE2L6
Description		TNF receptor associated factor 7	ubiquitin conjugating enzyme E2 L6
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleolus Plasma Membrane Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Binding ISG15 Transferase Activity Ubiquitin Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Ribosomal Large Subunit Assembly Apoptotic Process Notch Signaling Pathway Protein Ubiquitination Positive Regulation Of MAPK Cascade Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Apoptotic Signaling Pathway	Protein Polyubiquitination Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process ISG15-protein Conjugation
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Diastolic blood pressure ( 30578418) Height ( 28552196) Liver enzyme levels (alkaline phosphatase) ( 33972514) Pulse pressure ( 30578418) Systolic blood pressure ( 30578418)	Blood protein levels ( 28240269)
Interacting Genes		18 interacting genes: BTBD1 CDC42 CYLD HAGHL HDGF MAP3K3 NUDT16L1 OGT PBXIP1 PPIC RIPK4 TRAF6 UBE2D1 UBE2D2 UBE2D4 UBE2K UBE2L3 UBE2L6	40 interacting genes: ARHGDIA ARIH1 ARIH2 CBLC DTX3 FLT3 HERC5 LONRF1 MAP3K1 MID1 MUL1 NEDD4L PJA2 PRKN RBCK1 RBX1 RNF122 RNF125 RNF144A RNF144B RNF150 RNF19A RNF216 RNF25 RNF4 RNF40 RUNX1 SIAH1 SIAH2 SPEN TOPORS TRAF7 TRIM25 TRIM27 TRIM62 TRIM8 UBA1 UBA6 UBA7 UBE3A
Entrez ID		84231	9246
HPRD ID		06977	04867
Ensembl ID		ENSG00000131653	ENSG00000156587
Uniprot IDs		B3KQY7 Q6Q0C0	O14933
PDB IDs			1WZV 1WZW 2KJH
Enriched GO Terms of Interacting Partners?
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