UBE2L6 and RNF122

Number of citations of the paper that reports this interaction (PubMedID 19690564)
64

Data Source:
BioGRID (two hybrid)

		UBE2L6	RNF122
Description		ubiquitin conjugating enzyme E2 L6	ring finger protein 122
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytosol	Cytoplasm Endoplasmic Reticulum Golgi Apparatus Endomembrane System Integral Component Of Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Binding ISG15 Transferase Activity Ubiquitin Binding Ubiquitin Conjugating Enzyme Activity	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process ISG15-protein Conjugation	Negative Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination
Pathways		ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Blood protein levels ( 28240269)	Pulse pressure ( 30578418)
Interacting Genes		40 interacting genes: ARHGDIA ARIH1 ARIH2 CBLC DTX3 FLT3 HERC5 LONRF1 MAP3K1 MID1 MUL1 NEDD4L PJA2 PRKN RBCK1 RBX1 RNF122 RNF125 RNF144A RNF144B RNF150 RNF19A RNF216 RNF25 RNF4 RNF40 RUNX1 SIAH1 SIAH2 SPEN TOPORS TRAF7 TRIM25 TRIM27 TRIM62 TRIM8 UBA1 UBA6 UBA7 UBE3A	12 interacting genes: AQP1 CDS2 CTSA DDX58 GPR37L1 PLLP UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2L6 UBE2N
Entrez ID		9246	79845
HPRD ID		04867	11498
Ensembl ID		ENSG00000156587	ENSG00000133874
Uniprot IDs		O14933	Q9H9V4
PDB IDs		1WZV 1WZW 2KJH
Enriched GO Terms of Interacting Partners?
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