BRIP1 and HSD17B14

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		BRIP1	HSD17B14
Description		BRCA1 interacting helicase 1	hydroxysteroid 17-beta dehydrogenase 14
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Membrane	Cytosol
	Molecular Function	DNA Binding DNA Helicase Activity Chromatin Binding RNA Helicase Activity Protein Binding ATP Binding ATP Hydrolysis Activity 5'-3' DNA Helicase Activity Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding	Estradiol 17-beta-dehydrogenase Activity Protein Binding Identical Protein Binding 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity Testosterone 17-beta-dehydrogenase (NADP+) Activity
	Biological Process	DNA Damage Checkpoint Signaling Nucleotide-excision Repair Double-strand Break Repair Regulation Of Transcription By RNA Polymerase II Spermatogonial Cell Division Spermatid Development Negative Regulation Of Cell Population Proliferation Response To Toxic Substance Negative Regulation Of Gene Expression Meiotic DNA Double-strand Break Processing Involved In Reciprocal Meiotic Recombination DNA Duplex Unwinding Chiasma Assembly Cellular Response To Vitamin Cellular Response To Hypoxia Seminiferous Tubule Development Cellular Response To Angiotensin Double-strand Break Repair Involved In Meiotic Recombination	Steroid Catabolic Process
Pathways		Cytosolic iron-sulfur cluster assembly HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	Estrogen biosynthesis
Drugs
Diseases
GWAS		Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Ovarian cancer ( 21964575) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	Blood protein levels ( 30072576) Resting metabolic rate ( 28476931)
Interacting Genes		14 interacting genes: BLM BRCA1 CREBBP FANCD2 HDAC3 HNRNPC HPN HSD17B14 MRPS23 PATZ1 PECAM1 RPA1 SIRT1 TOPBP1	24 interacting genes: AKIRIN2 BRIP1 CA8 CDKN2D CYTOR DDIT3 INCA1 MIA3 MIR4435-2HG MPG NEK6 NTAQ1 NUDT18 OTUD3 PGLYRP3 PHF1 PICK1 PIDD1 PSMA1 REL SNAPC3 SNRPC SREK1IP1 TBC1D22B
Entrez ID		83990	51171
HPRD ID		05797	16801
Ensembl ID		ENSG00000136492	ENSG00000087076
Uniprot IDs		Q9BX63	A0A140VJH8 Q9BPX1
PDB IDs		1T15 1T29 3AL3	1YDE 5EN4 5HS6 5ICM 5ICS 5JS6 5JSF 5L7T 5L7W 5L7Y 5O42 5O43 5O6O 5O6X 5O6Z 5O72 5O7C 6EMM 6FFB 6G4L 6GBT 6GTB 6GTU 6H0M 6HNO 6QCK 6ZDE 6ZDI
Enriched GO Terms of Interacting Partners?
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