HSD17B14 and PIDD1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		HSD17B14	PIDD1
Description		hydroxysteroid 17-beta dehydrogenase 14	p53-induced death domain protein 1
Image
GO Annotations	Cellular Component	Cytosol	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol
	Molecular Function	Estradiol 17-beta-dehydrogenase Activity Protein Binding Identical Protein Binding 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity Testosterone 17-beta-dehydrogenase (NADP+) Activity	Endopeptidase Activity Death Receptor Binding Protein Binding
	Biological Process	Steroid Catabolic Process	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Protein Autoprocessing Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways		Estrogen biosynthesis	TP53 Regulates Transcription of Caspase Activators and Caspases
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Resting metabolic rate ( 28476931)	Breast cancer ( 29059683)
Interacting Genes		24 interacting genes: AKIRIN2 BRIP1 CA8 CDKN2D CYTOR DDIT3 INCA1 MIA3 MIR4435-2HG MPG NEK6 NTAQ1 NUDT18 OTUD3 PGLYRP3 PHF1 PICK1 PIDD1 PSMA1 REL SNAPC3 SNRPC SREK1IP1 TBC1D22B	15 interacting genes: AFP CASP2 CCDC85B CRADD EFEMP2 FADD HSD17B14 KHDC4 MADD MAFG MDFI MTNR1B POGZ SOX8 TEAD3
Entrez ID		51171	55367
HPRD ID		16801	11284
Ensembl ID		ENSG00000087076	ENSG00000177595
Uniprot IDs		A0A140VJH8 Q9BPX1	Q9HB75
PDB IDs		1YDE 5EN4 5HS6 5ICM 5ICS 5JS6 5JSF 5L7T 5L7W 5L7Y 5O42 5O43 5O6O 5O6X 5O6Z 5O72 5O7C 6EMM 6FFB 6G4L 6GBT 6GTB 6GTU 6H0M 6HNO 6QCK 6ZDE 6ZDI	2OF5
Enriched GO Terms of Interacting Partners?
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