BRIP1 and HPN

		BRIP1	HPN
Description		BRCA1 interacting helicase 1	hepsin
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Membrane	Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Cell Surface Integral Component Of Membrane Apical Plasma Membrane Nuclear Membrane Neuronal Cell Body Extracellular Exosome
	Molecular Function	DNA Binding DNA Helicase Activity Chromatin Binding RNA Helicase Activity Protein Binding ATP Binding ATP Hydrolysis Activity 5'-3' DNA Helicase Activity Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Serine-type Exopeptidase Activity
	Biological Process	DNA Damage Checkpoint Signaling Nucleotide-excision Repair Double-strand Break Repair Regulation Of Transcription By RNA Polymerase II Spermatogonial Cell Division Spermatid Development Negative Regulation Of Cell Population Proliferation Response To Toxic Substance Negative Regulation Of Gene Expression Meiotic DNA Double-strand Break Processing Involved In Reciprocal Meiotic Recombination DNA Duplex Unwinding Chiasma Assembly Cellular Response To Vitamin Cellular Response To Hypoxia Seminiferous Tubule Development Cellular Response To Angiotensin Double-strand Break Repair Involved In Meiotic Recombination	Proteolysis Regulation Of Cell Shape Positive Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Plasminogen Activation Positive Regulation Of Cell Growth Basement Membrane Disassembly Negative Regulation Of Apoptotic Process Positive Regulation By Host Of Viral Transcription Negative Regulation Of Epithelial Cell Proliferation Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Potassium Ion Transmembrane Transport Cochlea Morphogenesis Response To Thyroid Hormone Pilomotor Reflex Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Thyroid Hormone Generation
Pathways		Cytosolic iron-sulfur cluster assembly HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	MET Receptor Activation Signaling by MST1
Drugs			Bentiromide Benzylsulfonic acid CRA_1144 6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine
Diseases
GWAS		Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Ovarian cancer ( 21964575) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Liver enzyme levels (alkaline phosphatase) ( 33972514) Platelet count ( 32888494) Plateletcrit ( 32888494) Serum albumin level ( 23022100) Serum total protein level ( 29403010) Triglyceride levels ( 32203549 32154731) Urinary albumin-to-creatinine ratio ( 31511532) Urinary albumin-to-creatinine ratio in diabetes ( 31511532)
Interacting Genes		14 interacting genes: BLM BRCA1 CREBBP FANCD2 HDAC3 HNRNPC HPN HSD17B14 MRPS23 PATZ1 PECAM1 RPA1 SIRT1 TOPBP1	9 interacting genes: BNIP3 BRIP1 EGFR F7 GLP1R HGF MEGF8 SFTPC UPK2
Entrez ID		83990	3249
HPRD ID		05797	00801
Ensembl ID		ENSG00000136492	ENSG00000105707
Uniprot IDs		Q9BX63	A0A140VJK9 B7Z1L4 P05981
PDB IDs		1T15 1T29 3AL3	1O5E 1O5F 1P57 1Z8G 3T2N 5CE1
Enriched GO Terms of Interacting Partners?
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