MDC1 and PRIM1

Number of citations of the paper that reports this interaction (PubMedID 22990118)
49

Data Source:
BioGRID (two hybrid)

		MDC1	PRIM1
Description		mediator of DNA damage checkpoint 1	DNA primase subunit 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Focal Adhesion Nuclear Body	Nucleoplasm Alpha DNA Polymerase:primase Complex Membrane
	Molecular Function	Protein Binding Protein C-terminus Binding FHA Domain Binding	Magnesium Ion Binding DNA Primase Activity Protein Binding Zinc Ion Binding Ribonucleotide Binding
	Biological Process	DNA Repair Mitotic Intra-S DNA Damage Checkpoint Signaling	DNA Replication, Synthesis Of RNA Primer
Pathways		SUMOylation of DNA damage response and repair proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends TP53 Regulates Transcription of DNA Repair Genes G2/M DNA damage checkpoint	Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand Defective pyroptosis
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Eosinophil counts ( 31272903)	Appendicular lean mass ( 33097823) Asthma ( 31619474) Height ( 31562340) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Menopause (age at onset) ( 22267201 26414677) Monocyte count ( 32888494) Plateletcrit ( 32888494 27863252) Red blood cell count ( 29403010)
Interacting Genes		41 interacting genes: ANAPC1 ATM BARD1 BDKRB1 BRCA1 CASP3 CENPC CHEK2 COPS5 CREBBP CSNK2A1 DTX2 EP300 GATA4 H2AX HDAC10 HDAC8 HINFP NBN NCL NSD2 PIAS1 PIAS4 PRIM1 PTEN RAD50 RAD51 RNF8 SMC1A SRPK2 SUMO2 TNKS2 TP53 TP53BP1 UIMC1 USP13 USP15 USP28 VAMP5 WRN ZNF251	15 interacting genes: MDC1 MRPL38 NFE2 OGT PDE1B PRIM2 RAB5B RARG RPS26 SENP1 SLC11A2 SLC26A8 STAT6 TP53 YIF1A
Entrez ID		9656	5557
HPRD ID		16252	08899
Ensembl ID		ENSG00000137337	ENSG00000198056
Uniprot IDs		A0A1U9XBC1 A1Z5I9 Q14676	P49642
PDB IDs		2ADO 2AZM 2ETX 3K05 3UEO 3UMZ 3UN0 3UNM 3UNN 3UOT	4BPU 4BPW 4BPX 4LIK 4LIL 4MHQ 4RR2 5EXR 6R4S 6R4T 6R4U 6R5D 6R5E 6RB4
Enriched GO Terms of Interacting Partners?
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