USP9X and AFDN

Number of citations of the paper that reports this interaction (PubMedID 9722616)
36

Data Source:
HPRD (in vitro, in vivo)

		USP9X	AFDN
Description		ubiquitin specific peptidase 9 X-linked	afadin, adherens junction formation factor
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane Growth Cone	Nucleoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Nuclear Speck Cell Junction Cell-cell Contact Zone Pore Complex Tight Junction
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Protein Binding Cysteine-type Peptidase Activity Co-SMAD Binding Deubiquitinase Activity Lys48-specific Deubiquitinase Activity	Protein Binding Protein C-terminus Binding Small GTPase Binding Cadherin Binding Cell Adhesion Molecule Binding Actin Filament Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration Cell Cycle Chromosome Segregation Transforming Growth Factor Beta Receptor Signaling Pathway Female Gamete Generation Protein Localization Cell Migration Protein Ubiquitination Protein Deubiquitination BMP Signaling Pathway Regulation Of Circadian Rhythm Rhythmic Process Axon Extension Protein Stabilization Cell Division Protein K48-linked Deubiquitination Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Demethylation Amyloid Fibril Formation	Cell Adhesion Signal Transduction Cell-cell Signaling Positive Regulation Of Gene Expression Positive Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Migration Regulation Of Protein Localization Positive Regulation Of GTPase Activity Cell-cell Adhesion Mediated By Cadherin Pore Complex Assembly Establishment Of Protein Localization To Plasma Membrane Bicellular Tight Junction Assembly Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways		Downregulation of SMAD2/3:SMAD4 transcriptional activity Ub-specific processing proteases Synthesis of active ubiquitin: roles of E1 and E2 enzymes RHOU GTPase cycle RHOV GTPase cycle Peroxisomal protein import Peroxisomal protein import Amyloid fiber formation
Drugs			(5R)-2-sulfanyl-5-[4-(trifluoromethyl)benzyl]-1,3-thiazol-4(5H)-one
Diseases
GWAS		Migraine ( 27322543)	Number of alcoholic drinks required to feel an effect (long-term average) ( 31270906)
Interacting Genes		27 interacting genes: AFDN ALDH1A3 BCL9 CTNNB1 DCX DVL2 ERG FBXW7 GPSM1 MAP3K5 MCL1 NEAT1 PEX5 PSD4 PTEN RICTOR RNF115 RPGR SMAD2 SMAD4 SMN2 SMURF1 STIL SUMO2 TDRD3 UBC VHL	39 interacting genes: BCR CCR6 CTNNA1 EPHA7 EPHB2 EPHB3 EPHB6 F11R HRAS JAG1 LMO2 MRAS NECTIN1 NECTIN2 NECTIN3 NECTIN4 NRXN1 NRXN2 NRXN3 PFN1 PICK1 RALGDS RAP1A RAP1GAP RAP2A RIN1 RIT1 RIT2 RPS6KA2 RRAS RRAS2 SMAD2 SORBS1 SORBS2 SSX2IP TJP1 USP9X YWHAB YWHAG
Entrez ID		8239	4301
HPRD ID		02091	01164
Ensembl ID		ENSG00000124486	ENSG00000130396
Uniprot IDs		Q6P468 Q86X58 Q93008	A8MQ02 G1UI22 J3KN01 P55196
PDB IDs		5VBD 5WCH	1T2M 1XZ9 2AIN 2EXG 5A6C
Enriched GO Terms of Interacting Partners?
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