USP9X and RICTOR

Number of citations of the paper that reports this interaction (PubMedID 33378666)
2

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, enzymatic study)

		USP9X	RICTOR
Description		ubiquitin specific peptidase 9 X-linked	RPTOR independent companion of MTOR complex 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane Growth Cone	Cytosol TORC2 Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Protein Binding Cysteine-type Peptidase Activity Co-SMAD Binding Deubiquitinase Activity Lys48-specific Deubiquitinase Activity	Protein Binding Protein Kinase Binding Ribosome Binding Protein Serine/threonine Kinase Activator Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration Cell Cycle Chromosome Segregation Transforming Growth Factor Beta Receptor Signaling Pathway Female Gamete Generation Protein Localization Cell Migration Protein Ubiquitination Protein Deubiquitination BMP Signaling Pathway Regulation Of Circadian Rhythm Rhythmic Process Axon Extension Protein Stabilization Cell Division Protein K48-linked Deubiquitination Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Demethylation Amyloid Fibril Formation	Positive Regulation Of Endothelial Cell Proliferation Embryo Development Ending In Birth Or Egg Hatching Regulation Of Gene Expression Peptidyl-serine Phosphorylation Positive Regulation Of Actin Filament Polymerization Actin Cytoskeleton Reorganization Positive Regulation Of TOR Signaling Regulation Of Actin Cytoskeleton Organization Regulation Of Peptidyl-serine Phosphorylation TORC2 Signaling Regulation Of GTPase Activity Regulation Of Inflammatory Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Protein Kinase B Signaling Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Establishment Of Cell Polarity
Pathways		Downregulation of SMAD2/3:SMAD4 transcriptional activity Ub-specific processing proteases Synthesis of active ubiquitin: roles of E1 and E2 enzymes RHOU GTPase cycle RHOV GTPase cycle Peroxisomal protein import Peroxisomal protein import Amyloid fiber formation	PIP3 activates AKT signaling CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation
Drugs
Diseases
GWAS		Migraine ( 27322543)	Daytime sleep phenotypes ( 27126917) Immature fraction of reticulocytes ( 32888494) Obesity-related traits ( 23251661) Post bronchodilator FEV1 ( 26634245) Red blood cell count ( 32888494)
Interacting Genes		27 interacting genes: AFDN ALDH1A3 BCL9 CTNNB1 DCX DVL2 ERG FBXW7 GPSM1 MAP3K5 MCL1 NEAT1 PEX5 PSD4 PTEN RICTOR RNF115 RPGR SMAD2 SMAD4 SMN2 SMURF1 STIL SUMO2 TDRD3 UBC VHL	20 interacting genes: ANXA10 C5orf51 CHUK CTSW CUL1 EIF4EBP1 GSK3A GSK3B IFT20 IKBKB ILK MROH2B MTOR PHKB PLCXD3 PLK1 SGK1 SIAH1 SIRT1 USP9X
Entrez ID		8239	253260
HPRD ID		02091	10682
Ensembl ID		ENSG00000124486	ENSG00000164327
Uniprot IDs		Q6P468 Q86X58 Q93008	Q6R327
PDB IDs		5VBD 5WCH	5ZCS 6ZWM 6ZWO
Enriched GO Terms of Interacting Partners?
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