USP9X and STIL

Number of citations of the paper that reports this interaction (PubMedID 31197030)
5

Data Source:
BioGRID (enzymatic study)

		USP9X	STIL
Description		ubiquitin specific peptidase 9 X-linked	STIL centriolar assembly protein
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane Growth Cone	Cytoplasm Centrosome Centriole Cytosol
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Protein Binding Cysteine-type Peptidase Activity Co-SMAD Binding Deubiquitinase Activity Lys48-specific Deubiquitinase Activity	Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration Cell Cycle Chromosome Segregation Transforming Growth Factor Beta Receptor Signaling Pathway Female Gamete Generation Protein Localization Cell Migration Protein Ubiquitination Protein Deubiquitination BMP Signaling Pathway Regulation Of Circadian Rhythm Rhythmic Process Axon Extension Protein Stabilization Cell Division Protein K48-linked Deubiquitination Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Demethylation Amyloid Fibril Formation	Embryonic Axis Specification In Utero Embryonic Development Neural Tube Closure Heart Looping Mitotic Spindle Organization Smoothened Signaling Pathway Determination Of Left/right Symmetry Neural Tube Development Forebrain Development Notochord Development Floor Plate Development Multicellular Organism Growth Negative Regulation Of Apoptotic Process Regulation Of Centriole Replication Centrosome Duplication Protein Localization To Centrosome
Pathways		Downregulation of SMAD2/3:SMAD4 transcriptional activity Ub-specific processing proteases Synthesis of active ubiquitin: roles of E1 and E2 enzymes RHOU GTPase cycle RHOV GTPase cycle Peroxisomal protein import Peroxisomal protein import Amyloid fiber formation
Drugs
Diseases
GWAS		Migraine ( 27322543)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Clozapine-induced agranulocytosis ( 25187353) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Hip circumference adjusted for BMI ( 34021172) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		27 interacting genes: AFDN ALDH1A3 BCL9 CTNNB1 DCX DVL2 ERG FBXW7 GPSM1 MAP3K5 MCL1 NEAT1 PEX5 PSD4 PTEN RICTOR RNF115 RPGR SMAD2 SMAD4 SMN2 SMURF1 STIL SUMO2 TDRD3 UBC VHL	2 interacting genes: PIN1 USP9X
Entrez ID		8239	6491
HPRD ID		02091	01627
Ensembl ID		ENSG00000124486	ENSG00000123473
Uniprot IDs		Q6P468 Q86X58 Q93008	A0A0A0MR87 B7ZLW5 E9PSF2 Q15468 Q7Z626
PDB IDs		5VBD 5WCH	4YYP 5LHW 5LHZ
Enriched GO Terms of Interacting Partners?
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