RICTOR and C5orf51

		RICTOR	C5orf51
Description		RPTOR independent companion of MTOR complex 2	chromosome 5 open reading frame 51
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol TORC2 Complex	Nucleoplasm Cytosol
	Molecular Function	Protein Binding Protein Kinase Binding Ribosome Binding Protein Serine/threonine Kinase Activator Activity
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Embryo Development Ending In Birth Or Egg Hatching Regulation Of Gene Expression Peptidyl-serine Phosphorylation Positive Regulation Of Actin Filament Polymerization Actin Cytoskeleton Reorganization Positive Regulation Of TOR Signaling Regulation Of Actin Cytoskeleton Organization Regulation Of Peptidyl-serine Phosphorylation TORC2 Signaling Regulation Of GTPase Activity Regulation Of Inflammatory Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Protein Kinase B Signaling Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Establishment Of Cell Polarity
Pathways		PIP3 activates AKT signaling CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation
Drugs
Diseases
GWAS		Daytime sleep phenotypes ( 27126917) Immature fraction of reticulocytes ( 32888494) Obesity-related traits ( 23251661) Post bronchodilator FEV1 ( 26634245) Red blood cell count ( 32888494)
Interacting Genes		20 interacting genes: ANXA10 C5orf51 CHUK CTSW CUL1 EIF4EBP1 GSK3A GSK3B IFT20 IKBKB ILK MROH2B MTOR PHKB PLCXD3 PLK1 SGK1 SIAH1 SIRT1 USP9X	2 interacting genes: RICTOR SUOX
Entrez ID		253260	285636
HPRD ID		10682	11258
Ensembl ID		ENSG00000164327	ENSG00000205765
Uniprot IDs		Q6R327	A6NDU8
PDB IDs		5ZCS 6ZWM 6ZWO
Enriched GO Terms of Interacting Partners?
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