ORAI2 and GDF9

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ORAI2	GDF9
Description		ORAI calcium release-activated calcium modulator 2	growth differentiation factor 9
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Membrane Integral Component Of Membrane	Extracellular Space Cytoplasm
	Molecular Function	Protein Binding Store-operated Calcium Channel Activity	Cytokine Activity Growth Factor Activity Type I Activin Receptor Binding
	Biological Process	Store-operated Calcium Entry Calcium Ion Transmembrane Transport	Oocyte Growth Transforming Growth Factor Beta Receptor Signaling Pathway Female Gamete Generation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Cell Growth BMP Signaling Pathway SMAD Protein Signal Transduction Regulation Of Progesterone Secretion
Pathways		Elevation of cytosolic Ca2+ levels Ion homeostasis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases
GWAS		Chronotype ( 30696823 27494321) Morning vs. evening chronotype ( 27494321)	Asthma ( 31619474)
Interacting Genes		5 interacting genes: COPS6 GDF9 MED31 SETDB1 UNC119	46 interacting genes: ACVR2A ADPGK ANXA7 APLP1 BMP15 BMPR1A BMPR1B BMPR2 BTBD2 CDKN1A CDKN2C CRELD1 DLEU1 DNM2 FOXG1 FXYD6 GADD45G HSPA9 ILF3 KDM1A KIF22 LSM3 MOB4 MPHOSPH6 MYCBP NDUFB9 ORAI2 PABPC4 PAFAH1B3 PCDHA4 PCYT2 PMF1 PRKRA PSMD11 RAB27A RSRC1 S100A8 SAT1 SERPINB9 SMN1 SNRPG STRN4 TDGF1 TK1 TRIB3 WASHC3
Entrez ID		80228	2661
HPRD ID		09860	03560
Ensembl ID		ENSG00000160991	ENSG00000164404
Uniprot IDs		B4DUB4 Q96SN7	B4DXG3 O60383
PDB IDs
Enriched GO Terms of Interacting Partners?
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