DHRS11 and DLG3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		DHRS11	DLG3
Description		dehydrogenase/reductase 11	discs large MAGUK scaffold protein 3
Image
GO Annotations	Cellular Component	Cellular_component Extracellular Region	Extracellular Space Cytosol Plasma Membrane Bicellular Tight Junction Basolateral Plasma Membrane Cell Junction Growth Cone AMPA Glutamate Receptor Complex Neuronal Cell Body Dendritic Shaft Glutamatergic Synapse Postsynaptic Density, Intracellular Component
	Molecular Function	Nucleotide Binding 3-keto Sterol Reductase Activity Estradiol 17-beta-dehydrogenase Activity 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity 17-beta-ketosteroid Reductase Activity 17-beta-hydroxysteroid Dehydrogenase (NADP+) Activity	Protein Binding Protein C-terminus Binding Kinase Binding Phosphatase Binding Protein Phosphatase Binding PDZ Domain Binding Ubiquitin Protein Ligase Binding Ionotropic Glutamate Receptor Binding Structural Constituent Of Postsynaptic Density
	Biological Process	Steroid Biosynthetic Process Estrogen Biosynthetic Process	Establishment Of Planar Polarity Negative Regulation Of Cell Population Proliferation Embryo Development Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Protein Tyrosine Kinase Activity Receptor Localization To Synapse Cell-cell Adhesion Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Maintenance Of Postsynaptic Density Structure
Pathways			Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor NrCAM interactions Activation of Ca-permeable Kainate Receptor RAF/MAP kinase cascade Neurexins and neuroligins Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs		Nicotinamide adenine dinucleotide phosphate
Diseases
GWAS		Body mass index ( 26426971) Estimated glomerular filtration rate ( 31015462)	Mean platelet volume ( 32888494)
Interacting Genes		2 interacting genes: DLG3 GSDMB	49 interacting genes: ABCA1 ADGRL1 APC ATP2B4 CACNG2 CALM1 CNKSR2 CRIPT DHRS11 DLG1 DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 EIF4H ERBB4 EXOC4 EXOC7 GDA GLS2 GRIK2 GRIN1 GRIN2A GRIN2B GRIN2C GUCY1A2 KCNA4 KCNJ12 KCNJ2 KDELR1 KHDRBS1 KIF1B LIN7A LRP2 MAPK12 NLGN1 NLGN2 NLGN3 OGT OSBP2 PLEKHA2 PTK2B RPS8 SCN4A SCN5A SEMA4C SYNGAP1 VTN
Entrez ID		79154	1741
HPRD ID		08331	02177
Ensembl ID		ENSG00000278535	ENSG00000082458
Uniprot IDs		A0A024R0T1 Q6UWP2	Q59FY1 Q92796
PDB IDs		1XG5	1UM7 2FE5 2I1N
Enriched GO Terms of Interacting Partners?
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