DLG3 and PLEKHA2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		DLG3	PLEKHA2
Description		discs large MAGUK scaffold protein 3	pleckstrin homology domain containing A2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytosol Plasma Membrane Bicellular Tight Junction Basolateral Plasma Membrane Cell Junction Growth Cone AMPA Glutamate Receptor Complex Neuronal Cell Body Dendritic Shaft Glutamatergic Synapse Postsynaptic Density, Intracellular Component	Nucleus Cytoplasm Plasma Membrane Membrane Protein-containing Complex
	Molecular Function	Protein Binding Protein C-terminus Binding Kinase Binding Phosphatase Binding Protein Phosphatase Binding PDZ Domain Binding Ubiquitin Protein Ligase Binding Ionotropic Glutamate Receptor Binding Structural Constituent Of Postsynaptic Density	Fibronectin Binding Protein Binding Lipid Binding PDZ Domain Binding Laminin Binding Phosphatidylinositol-3,4-bisphosphate Binding
	Biological Process	Establishment Of Planar Polarity Negative Regulation Of Cell Population Proliferation Embryo Development Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Protein Tyrosine Kinase Activity Receptor Localization To Synapse Cell-cell Adhesion Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Maintenance Of Postsynaptic Density Structure	Positive Regulation Of Cell-matrix Adhesion
Pathways		Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor NrCAM interactions Activation of Ca-permeable Kainate Receptor RAF/MAP kinase cascade Neurexins and neuroligins Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation	Synthesis of PIPs at the plasma membrane
Drugs
Diseases
GWAS		Mean platelet volume ( 32888494)	High density lipoprotein cholesterol levels ( 31211820) Monocyte percentage of white cells ( 32888494)
Interacting Genes		49 interacting genes: ABCA1 ADGRL1 APC ATP2B4 CACNG2 CALM1 CNKSR2 CRIPT DHRS11 DLG1 DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 EIF4H ERBB4 EXOC4 EXOC7 GDA GLS2 GRIK2 GRIN1 GRIN2A GRIN2B GRIN2C GUCY1A2 KCNA4 KCNJ12 KCNJ2 KDELR1 KHDRBS1 KIF1B LIN7A LRP2 MAPK12 NLGN1 NLGN2 NLGN3 OGT OSBP2 PLEKHA2 PTK2B RPS8 SCN4A SCN5A SEMA4C SYNGAP1 VTN	19 interacting genes: COG6 DLG2 DLG3 EGLN3 FHL5 GIPC1 GIPC2 GIPC3 GOLGA2 HSF2BP KANK2 LNX1 M1AP MPDZ PLEKHA1 PTPN13 SNTG1 TEPSIN TRIM23
Entrez ID		1741	59339
HPRD ID		02177
Ensembl ID		ENSG00000082458	ENSG00000169499
Uniprot IDs		Q59FY1 Q92796	A0A087WZ32 A8K727 Q9HB19
PDB IDs		1UM7 2FE5 2I1N
Enriched GO Terms of Interacting Partners?
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