DLG3 and DLGAP2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		DLG3	DLGAP2
Description		discs large MAGUK scaffold protein 3	DLG associated protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytosol Plasma Membrane Bicellular Tight Junction Basolateral Plasma Membrane Cell Junction Growth Cone AMPA Glutamate Receptor Complex Neuronal Cell Body Dendritic Shaft Glutamatergic Synapse Postsynaptic Density, Intracellular Component	Neurofilament Plasma Membrane Postsynaptic Density Glutamatergic Synapse Postsynaptic Specialization
	Molecular Function	Protein Binding Protein C-terminus Binding Kinase Binding Phosphatase Binding Protein Phosphatase Binding PDZ Domain Binding Ubiquitin Protein Ligase Binding Ionotropic Glutamate Receptor Binding Structural Constituent Of Postsynaptic Density	Protein Binding Molecular Adaptor Activity
	Biological Process	Establishment Of Planar Polarity Negative Regulation Of Cell Population Proliferation Embryo Development Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Protein Tyrosine Kinase Activity Receptor Localization To Synapse Cell-cell Adhesion Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Maintenance Of Postsynaptic Density Structure	Neuron-neuron Synaptic Transmission Regulation Of Postsynaptic Neurotransmitter Receptor Activity
Pathways		Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor NrCAM interactions Activation of Ca-permeable Kainate Receptor RAF/MAP kinase cascade Neurexins and neuroligins Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs
Diseases
GWAS		Mean platelet volume ( 32888494)	Bipolar disorder ( 31043756) Daytime nap ( 33568662) End-stage renal disease ( 29885931) Eye morphology ( 29921221) Lung cancer ( 28604730) Menarche (age at onset) ( 23599027) Neuritic plaque ( 31497858) Post bronchodilator FEV1/FVC ratio ( 26634245) Refractive astigmatism ( 30306274) Stroke ( 32693751) Tau burden ( 33426524) Triglycerides ( 24886709) White matter microstructure in first episode schizophrenia (right posterior cingulate cortex) ( 28924203)
Interacting Genes		49 interacting genes: ABCA1 ADGRL1 APC ATP2B4 CACNG2 CALM1 CNKSR2 CRIPT DHRS11 DLG1 DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 EIF4H ERBB4 EXOC4 EXOC7 GDA GLS2 GRIK2 GRIN1 GRIN2A GRIN2B GRIN2C GUCY1A2 KCNA4 KCNJ12 KCNJ2 KDELR1 KHDRBS1 KIF1B LIN7A LRP2 MAPK12 NLGN1 NLGN2 NLGN3 OGT OSBP2 PLEKHA2 PTK2B RPS8 SCN4A SCN5A SEMA4C SYNGAP1 VTN	20 interacting genes: ABI2 ADRB1 CYSRT1 DGCR6 DLG2 DLG3 DLG4 DLGAP1 GRK5 KRT40 KRTAP4-2 MAGI2 NLGN4X NOS1 PINX1 SHANK2 SHANK3 SORBS2 TSPOAP1 UBASH3B
Entrez ID		1741	9228
HPRD ID		02177	09258
Ensembl ID		ENSG00000082458	ENSG00000198010
Uniprot IDs		Q59FY1 Q92796	A0A1B0GTN4
PDB IDs		1UM7 2FE5 2I1N
Enriched GO Terms of Interacting Partners?
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