VKORC1 and HPR

Number of citations of the paper that reports this interaction (PubMedID 21103663)
9

Data Source:
BioGRID (two hybrid)

		VKORC1	HPR
Description		vitamin K epoxide reductase complex subunit 1	haptoglobin-related protein
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space Spherical High-density Lipoprotein Particle Extracellular Exosome Blood Microparticle
	Molecular Function	Protein Binding Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Quinone Binding	Serine-type Endopeptidase Activity Hemoglobin Binding
	Biological Process	Xenobiotic Metabolic Process Blood Coagulation Peptidyl-glutamic Acid Carboxylation Vitamin K Metabolic Process Bone Development	Acute Inflammatory Response Positive Regulation Of Cell Death Zymogen Activation
Pathways		Metabolism of vitamin K	Scavenging of heme from plasma
Drugs		Menadione Dicoumarol Phenindione Warfarin Phenprocoumon Acenocoumarol	Zinc Copper Zinc acetate
Diseases
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body fat distribution (arm fat ratio) ( 30664634) Warfarin maintenance dose ( 18535201 20833655 19300499 26265036) Warfarin maintenance dose (adjusted for clinical factors) ( 28686080)	Alanine aminotransferase levels ( 34315874) Apolipoprotein A1 levels ( 33730874) Aspartate aminotransferase levels ( 33547301 34315874) Blood protein levels ( 28240269) Cholesterol, total ( 24097068 28270201 25961943 20686565 26582766) Coronary artery disease ( 32469254 33020668) Hematocrit ( 32888494) LDL cholesterol ( 24097068 25961943 20686565 26582766) LDL cholesterol levels ( 28334899 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 22001757) Low density lipoprotein cholesterol levels ( 32154731 33339817) Metabolite levels ( 22916037) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Total cholesterol levels ( 28334899) Triglyceride levels ( 32154731) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		94 interacting genes: AHSG APLP2 APOA1 APOA2 APOC1 APOC3 APOC4 ARL6IP5 ASGR1 ASGR2 ATP5MC3 ATP6AP2 BCAP31 C1S CCDC12 CCDC167 CD63 CD81 CD9 CLDN10 CNN3 COMT CPLX4 CREB3 CREB3L1 CXADR DCTPP1 DPM2 ECHDC1 FAM209A FAM210B FGG FGL1 FIS1 FTL GJB1 GORAB GPR152 HAMP HDAC6 HOMER2 HP HPR HSD17B7 IFITM3 JAGN1 KCNK17 LIG4 LMNA MANBAL METTL7B MSMO1 MSRB1 MT1X MUC1 PCDH1 PCMT1 PDIA6 PIGH PLP2 PPA2 PPIB PROCR REEP5 RMDN1 RMDN3 RMND5A SAA1 SAT1 SERPINA1 SLC15A3 SLC22A2 SLC25A1 SLC31A2 SLC7A14 SNORA12 SPTSSA STAT6 SURF4 TF TMBIM4 TMEM120A TMEM134 TMEM176A TMEM230 TMEM242 TMEM256 TMEM35B TMEM45B TRAM1 TREX1 VAPB YIF1A ZCCHC24	6 interacting genes: APOA1 DYNC1LI2 HSP90AA1 IGHM PSKH1 VKORC1
Entrez ID		79001	3250
HPRD ID		10540	00773
Ensembl ID		ENSG00000167397	ENSG00000261701
Uniprot IDs		A0A0S2Z5X7 A0A0S2Z6I4 Q9BQB6	P00739
PDB IDs		6WV3 6WV4 6WV5 6WV6 6WV7 6WVH
Enriched GO Terms of Interacting Partners?
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